The Quebec Newborn Twin Study at 21
The Quebec Newborn Twin Study at 21
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DOI：
10.1017/thg.2019.74
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发表时间：
2019-12-01
影响因子：
0.9
通讯作者：
Vitaro, Frank
中科院分区：
文献类型：
--
作者：
Boivin, Michel;Brendgen, Mara;Vitaro, Frank
本文是对魁北克新生儿双胞胎研究（QNTS）先前描述的修订和更新版本，该研究是对1995年至1998年出生于加拿大魁北克大蒙特利尔地区的双胞胎出生队列的持续前瞻性纵向随访。QNTS的目标是记录儿童期发育健康的认知，行为和社会情感方面的个体差异，他们的早期遗传和环境决定因素，以及他们在以后的社会情绪调整，学校，健康和职业结果中的假定作用。共有662个双胞胎家庭在双胞胎6个月大时进行了初步评估。这对双胞胎和他们的家人随后定期接受随访。QNTS现在已经收集或计划收集16波数据，包括5波学前教育数据。在过去的24年里，广泛的生理，认知，行为，学校和健康表型纵向记录通过多信息和多方法测量。QNTS还需要对近端（例如，养育行为，同伴关系）和远端（例如，家庭收入）的特点，孩子的环境。QNTS儿童和他们父母的一个子集已经进行了基因分型，允许计算各种多基因评分。这种详细的纵向信息使得QNTS特别适合于研究早期发育和基因-环境关系的作用。
This paper is a revised and updated edition of a previous description of the Quebec Newborn Twin Study (QNTS), an ongoing prospective longitudinal follow-up of a birth cohort of twins born between 1995 and 1998 in the greater Montreal area, Quebec, Canada. The goal of QNTS is to document individual differences in the cognitive, behavioral, and social-emotional aspects of developmental health across childhood, their early genetic and environmental determinants, as well as their putative role in later social-emotional adjustment, school, health, and occupational outcomes. A total of 662 families of twins were initially assessed when the twins were aged 6 months. These twins and their family were then followed regularly. QNTS now has 16 waves of data collected or planned, including 5 in preschool. Over the last 24 years, a broad range of physiological, cognitive, behavioral, school, and health phenotypes were documented longitudinally through multi-informant and multimethod measurements. QNTS also entails extended and detailed multilevel assessments of proximal (e.g., parenting behaviors, peer relationships) and distal (e.g., family income) features of the child's environment. QNTS children and a subset of their parents have been genotyped, allowing for the computation of a variety of polygenic scores. This detailed longitudinal information makes QNTS uniquely suited for the study of the role of the early years and gene-environment transactions in development.