Factors associated with the impossibility to obtain reliable liver stiffness measurements by means of Acoustic Radiation Force Impulse (ARFI) elastography-Analysis of a cohort of 1031 subjects
Factors associated with the impossibility to obtain reliable liver stiffness measurements by means of Acoustic Radiation Force Impulse (ARFI) elastography-Analysis of a cohort of 1031 subjects
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DOI：
10.1016/j.ejrad.2013.11.019
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发表时间：
2014-02-01
影响因子：
3.3
通讯作者：
Gradinaru-Tascau, Oana
中科院分区：
文献类型：
--
作者：
Bota, Simona;Sporea, Ioan;Gradinaru-Tascau, Oana
简介：声辐射力脉冲（ARFI）弹性成像是一种非侵入性的技术，用于肝纤维化assessment.Aim：为了评估的可行性ARFI弹性成像在一个大的队列的科目，并确定相关的因素不可能获得可靠的肝硬度（LS）measurements by means of this technique.Methods：我们的回顾性研究包括1031例成人受试者有或没有慢性肝病。在每例受试者中，通过ARFI弹性成像评估LS。如果在至少10次注射后未获得有效测量结果，并且在以下情况下不可靠，则定义为ARFI测量失败：少于10次有效注射;或10次有效测量的中值，成功率（SR）= 30%。在4名受试者中观察到通过ARFI进行LS测量失败66例（6.4%）测量结果不可靠，故961例（93.3%）测量结果可靠。在单变量分析中，以下风险因素与失败和不可靠的测量相关：年龄超过58岁（OR = 0.49; 95% CI 0.30-0.80，p = 0.005），男性（OR = 0.58; 95%CI 0.34-0.94，p = 0.04），BMI > 27.7 kg/m2（OR = 0.23，95%CI 0.13-0.41，p < 0.0001）。在多变量分析中，上述所有因素均与失败和不可靠的measurement.Conclusions：可靠的LS测量ARFI弹性成像的方法，在93.3%的情况下获得的风险。年龄较大、BMI较高和男性与测量失败和不可靠的风险相关，但与瞬态弹性成像相比，其影响有限。(C)2013爱思唯尔爱尔兰有限公司版权所有。
Introduction: Acoustic Radiation Force Impulse (ARFI) elastography is a non-invasive technique for liver fibrosis assessment.Aim: To assess the feasibility of ARFI elastography in a large cohort of subjects and to identify factors associated with impossibility to obtain reliable liver stiffness (LS) measurements by means of this technique.Methods: Our retrospective study included 1031 adult subjects with or without chronic liver disease. In each subject LS was assessed by means of ARFI elastography. Failure of ARFI measurements was defined if no valid measurement was obtained after at least 10 shots and unreliable in the following situations: fewer than 10 valid shots; or median value of 10 valid measurements with a success rate (SR) = 30%.Results: Failure of LS measurements by means of ARFI was observed in 4 subjects (0.3%), unreliable measurements in 66 subjects (6.4%), so reliable measurements were obtained in 961 subjects (93.3%). In univariant analysis, the following risk factors were associated with failed and unreliable measurements: age over 58 years (OR = 0.49; 95% CI 0.30-0.80, p = 0.005), male gender (OR = 0.58; 95% CI 0.34-0.94, p = 0.04), BMI > 27.7 kg/m(2) (OR = 0.23, 95% CI 0.13-0.41, p < 0.0001). In multivariate analysis all the factors mentioned above were independently associated with the risk of failed and unreliable measurements.Conclusions: Reliable LS measurements by means of ARFI elastography were obtained in 93.3% of cases. Older age, higher BMI and male gender were associated with the risk of failed and unreliable measurements, but their influence is limited as compared with Transient Elastography. (C) 2013 Elsevier Ireland Ltd. All rights reserved.