Is headache related to asthma, hay fever, and chronic bronchitis? The Head-HUNT study
Is headache related to asthma, hay fever, and chronic bronchitis? The Head-HUNT study
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DOI：
10.1111/j.1526-4610.2006.00597.x
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发表时间：
2007-02-01
期刊：
影响因子：
5
通讯作者：
Zwart, John-Anker
中科院分区：
文献类型：
--
作者：
Aamodt, Anne H.;Stovner, Lars J.;Zwart, John-Anker
目的 - 在一项基于人群的大型横断面研究中，探讨偏头痛和非偏头痛与哮喘、花粉症和慢性支气管炎之间的关系。背景 - 偏头痛与哮喘或过敏之间的关联已在临床和流行病学研究中得到证实，而关于慢性支气管炎的研究却很少。方法 - 共有 51,383 名受试者完成了头痛问卷，并构成了“Head-HUNT”研究。其中 50,401 人（98.1%）回答了有关哮喘和慢性支气管炎的问题，47,029 人（91.5%）回答了有关花粉热的问题。通过多变量分析评估相关性，以 95% 置信区间 (CI) 估计患病率比值比 (OR)。结果 - 患有当前哮喘、哮喘相关症状、花粉热和慢性支气管炎的患者中，偏头痛和非偏头痛的可能性大约是没有哮喘、哮喘相关症状、花粉热和慢性支气管炎的患者的 1.5 倍。这种关联随着头痛频率的增加而增加。结论。-这项基于问卷的大型研究证实，偏头痛和其他头痛与呼吸系统和过敏性疾病有关。头痛与哮喘、花粉热和慢性支气管炎之间的关联程度往往处于同一顺序。与头痛诊断相比，头痛频率似乎对呼吸系统或过敏性疾病的影响更大。是否存在因果关系尚不确定，但结果强调了在频繁头痛的患者中考虑合并症的重要性。
Objectives.-To examine the relationship between migraine and nonmigrainous headache and asthma, hay fever, and chronic bronchitis in a large cross-sectional population-based study.Background.-Associations between prevalence of migraine and asthma or allergy have been demonstrated in clinic-based and epidemiologic studies whereas studies on chronic bronchitis are scarce.Methods.-A total of 51,383 subjects completed a headache questionnaire and constituted the "Head-HUNT" Study. Of these 50,401 (98.1%) answered the questions about asthma and chronic bronchitis, and 47,029 (91.5%) answered the question about hay fever. Associations were assessed in multivariate analyses, estimating prevalence odds ratios (ORs) with 95% confidence intervals (CI).Results.-Both migraine and nonmigrainous headache were approximately 1.5 times more likely among those with current asthma, asthma related symptoms, hay fever, and chronic bronchitis than those without. The association increased with increasing headache frequency.Conclusions.-This large questionnaire-based study confirms that migraine and other headaches are associated with respiratory and allergic disorders. The magnitude of the association between headache and asthma, hay fever, and chronic bronchitis tended to be in the same order. Headache frequency seems to have a greater impact on the association with respiratory or allergic conditions than headache diagnoses. Whether it is a causal relationship is uncertain, but the results underline the importance of considering comorbid disorders among patients with frequent headache.