Alpinia pricei Hayata rhizome extracts have suppressive and preventive potencies against hypercholesterolemia
Alpinia pricei Hayata rhizome extracts have suppressive and preventive potencies against hypercholesterolemia
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DOI：
10.1016/j.fct.2010.05.070
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发表时间：
2010-08-01
影响因子：
4.3
通讯作者：
Lin, C. F.
中科院分区：
文献类型：
--
作者：
Chang, N. W.;Wu, C. T.;Lin, C. F.
本研究旨在探讨苦山姜70%乙醇提取物（APE）对大鼠血脂及脂质过氧化作用的影响。给叙利亚仓鼠喂食基于咀嚼的高胆固醇血症饮食（HCD）2周以诱导高胆固醇血症（>250 mg/dl）。为了评价APE抑制高胆固醇血症的效力，然后给仓鼠喂食HCD加高剂量（500 mg/kg体重）或低剂量（250 mg/kg体重）的APE，或仅HCD另外4周。结果发现，高剂量APE可降低高胆固醇血症仓鼠血清总胆固醇（TC）和低密度脂蛋白胆固醇（LDL-C）水平，降低硫代巴比妥酸反应物质（TBARS）和丙氨酸氨基转移酶（ALT）活性，降低动脉粥样硬化指数（AI），（LDL-C/HDL-C和TC/HDL-C比值），以及过氧化物酶体增殖物激活受体γ（PPARy）的肝蛋白表达低于喂食HCD饮食的仓鼠。此外，我们还确定了APE对喂食HCD 6周的仓鼠的预防作用。高剂量APE和HCD联合喂养6周的仓鼠也发现了降低胆固醇的作用。这些结果表明，APE对高胆固醇血症具有抑制和预防作用，并具有保护脂质过氧化作用。(C)2010年由Elsevier Ltd.出版
The aim of this study was to investigate the effects of 70% ethanol extracts of Alpinia pricei (APE) on lipid profiles and lipid peroxidation. Syrian hamsters were fed a chow-based hypercholesterolemic diet (HCD) for 2 weeks to induce hypercholesterolemia (>250 mg/dl). To evaluate the potency of APE in suppressing hypercholesterolemia, hamsters were then fed HCD plus a high dose (500 mg/kg body weight) or a low dose (250 mg/kg body weight) of APE, or only HCD for another 4 weeks. We found that hypercholesterolemic hamsters fed a high dose of APE had lower serum total cholesterol (TC) and low-density lipoprotein-cholesterol (LDL-C) levels, lower thiobarbituric acid reactive substances (TBARS) and alanine aminotransferase (ALT) activities, lower atherogenic indices (LDL-C/HDL-C and TC/HDL-C ratios), and lower hepatic protein expression of peroxisome proliferators activated receptor gamma (PPARy) than hamsters fed a HCD diet. In addition, we also determined the preventive effects of APE on hamsters fed a HCD for 6 weeks. The hypocholesterolemic effects were also found in hamsters co-fed a high dose of APE and HCD for 6 weeks. These results suggest that APE has both suppressive and preventive potencies against hypercholesterolemia and has the potency to protect against lipid peroxidation. (C) 2010 Published by Elsevier Ltd.