Nationwide prevalence of inflammatory bowel disease in Sweden: a population-based register study
Nationwide prevalence of inflammatory bowel disease in Sweden: a population-based register study
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DOI：
10.1111/apt.12528
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发表时间：
2014-01-01
影响因子：
7.6
通讯作者：
Neovius, M.
中科院分区：
文献类型：
--
作者：
Busch, K.;Ludvigsson, J. F.;Neovius, M.
背景炎症性肠病（IBD）的区域性研究表明患病率随着时间的推移而增加，但到目前为止还没有全国性的估计。目的估计2010年瑞典总体IBD患病率，按疾病和特定患者细分。方法根据住院治疗中溃疡性结肠炎和克罗恩病的国际分类代码确定患者（1987-2010年），日间手术和非初级门诊护理结果2010年瑞典共有61344名医生诊断为IBD的患者在非初级保健中被诊断为IBD，（平均年龄50岁; 51%为男性），对应的患病率为0.65%（95%CI，0.65-0.66）。患病率随年龄增长而增加，女性在50- 59岁时达到高峰，男性在60- 69岁时达到高峰。增加IBD作为主要（与主要或贡献）诊断代码的要求，或内科/胃肠病学/外科的诊断没有改变患病率估计。积极治疗疾病的患病率（定义为两个或两个以上的IBD相关的访问，其中一个发生在2010年，加上至少一个分发的IBD相关药物处方在2010年）为0.27%（95%CI，0.27-0.28）。虽然患病率估计在不同的病例定义中是稳健的，但一旦需要两次或两次以上的就诊，2010年只有大约三分之一的患病患者从专科护理中获得资源。
BackgroundRegional studies on inflammatory bowel disease (IBD) suggest an increasing prevalence over time, but no nationwide estimate has been published so far.AimTo estimate the IBD prevalence in 2010 in Sweden overall, by disease, and in specific patient segments.MethodsPatients were identified according to international classification codes for ulcerative colitis and Crohn's disease in in-patient care (1987-2010), day surgery and nonprimary out-patient care (1997-2010) in the nationwide Swedish Patient Register.ResultsRequiring two or more diagnoses of IBD in nonprimary care, a total of 61344 individuals with physician-diagnosed IBD were alive in Sweden in 2010 (mean age 50years; 51% men), corresponding to a prevalence of 0.65% (95% CI, 0.65-0.66). The prevalence increased with age, and peaked in women at ages 50-59years and in men at ages 60-69years. Adding the requirement of IBD as main (vs. main or contributory) diagnosis code, or diagnosis from an internal medicine/gastroenterology/surgery department did not change the prevalence estimate. Prevalence of actively treated disease (defined as two or more IBD-related visits, of which one occurred in 2010, plus at least one dispensed prescription of IBD-related drugs in 2010) was 0.27% (95% CI, 0.27-0.28).ConclusionsThe Swedish nationwide register-based IBD prevalence was higher compared with previous Swedish and international estimates. While prevalence estimates were robust across different case definitions, once two or more visits were required, only about one-third of prevalent patients were drawing resources from specialised care in 2010.