Excitotoxin-induced myocardial necrosis.
Excitotoxin-induced myocardial necrosis.
复制标题
兴奋毒素引起的心肌坏死。
DOI：
10.1016/0014-2999(89)90379-8
复制
发表时间：
1989
影响因子：
5
通讯作者：
Clower,BR
中科院分区：
文献类型：
--
作者：
Rockhold,RW;Acuff,CG;Clower,BR
将兴奋毒素kainic酸和n -甲基- d -天冬氨酸（NMDA）双侧注射到大鼠室旁下丘脑。戊巴比妥麻醉大鼠后，Kainic酸可引起升压反应、心动过速和心源性猝死。氟烷麻醉停止后，注射NMDA对心血管有刺激作用。NMDA后48 h可见心内出血、透明心肌坏死、单核炎症为主。拉贝他洛尔预处理既不能预防也不能静脉注射NMDA引起这些变化。下丘脑内兴奋毒素注射引起有害的心肌改变。
The excitotoxins, kainic acid and N-methyl-D-aspartic acid (NMDA), were injected bilaterally into the paraventricular hypothalamus of rats. Kainic acid elicited pressor responses, tachycardia and sudden cardiac death in Nembutal® -anesthesized rats. Injections of NMDA caused cardiovascular stimulation on cessation of halothane anesthesia. Intramyocardial hemorrhage, hyaline myocardial necrosis and predominantly mononuclear inflammation were evident 48 h following NMDA. Labetalol pretreatment did not protect from nor did i.v. NMDA cause these changes. Intrahypothalamic excitotoxin injections cause deleterious myocardial changes.