Towards an optimal paradigm for simultaneously recording cortical and brainstem auditory evoked potentials
Towards an optimal paradigm for simultaneously recording cortical and brainstem auditory evoked potentials
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DOI：
10.1016/j.jneumeth.2014.12.019
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发表时间：
2015-02-15
影响因子：
3
通讯作者：
Bidelman, Gavin M.
中科院分区：
文献类型：
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作者：
Bidelman, Gavin M.
背景资料：脑干和皮层事件相关脑电位（ERP）的同时记录可以提供一个有价值的工具，了解早期的神经转录的行为相关的声音和层次的信号处理操作在多个层次的听觉系统。迄今为止，双重记录已经受到技术和生理限制的挑战，包括引出每类ERP所需的不同最佳参数（例如，差异适应/居住效应和试验次数，以获得足够的反应信噪比）。新方法：我们研究了一种新的刺激范式，用于同时记录听觉脑干频率跟随反应（FFR）和皮层ERP。该范例是“最佳的”，因为它使用了群集刺激呈现和可变的刺激间间隔（ISI）来（i）实现用于引发皮层下和皮层响应的最理想的采集参数，（ii）获得足够数量的试验来检测每类响应，以及（iii）最小化神经适应/习惯化效应。集群和传统（固定，慢ISI）刺激模式之间的比较显示，脑干FFR或皮质ERP的振幅或波幅变化极小。集群的范例提供了超过3倍的记录效率增加相比，传统的（固定ISI介绍），因此，一个更快速的协议，获得双脑干皮层录音在个别listener.Conclusions：我们推断，更快的记录皮层下和皮层电位可能允许更完整和敏感的测试的神经生理功能和援助的听觉功能的差异评估。(C)2014 Elsevier B. V.版权所有。
Background: Simultaneous recording of brainstem and cortical event-related brain potentials (ERPs) may offer a valuable tool for understanding the early neural transcription of behaviorally relevant sounds and the hierarchy of signal processing operating at multiple levels of the auditory system. To date, dual recordings have been challenged by technological and physiological limitations including different optimal parameters necessary to elicit each class of ERP (e.g., differential adaptation/habitation effects and number of trials to obtain adequate response signal-to-noise ratio).New method: We investigated a new stimulus paradigm for concurrent recording of the auditory brainstem frequency-following response (FFR) and cortical ERPs. The paradigm is "optimal" in that it uses a clustered stimulus presentation and variable interstimulus interval (ISI) to (i) achieve the most ideal acquisition parameters for eliciting subcortical and cortical responses, (ii) obtain an adequate number of trials to detect each class of response, and (iii) minimize neural adaptation/habituation effects.Results and comparison with existing method: Comparison between clustered and traditional (fixed, slow ISI) stimulus paradigms revealed minimal change in amplitude or latencies of either the brainstem FFR or cortical ERP. The clustered paradigm offered over a 3 x increase in recording efficiency compared to conventional (fixed ISI presentation) and thus, a more rapid protocol for obtaining dual brainstem-cortical recordings in individual listeners.Conclusions: We infer that faster recording of subcortical and cortical potentials might allow more complete and sensitive testing of neurophysiological function and aid in the differential assessment of auditory function. (C) 2014 Elsevier B.V. All rights-reserved.