D-serine improves dimensions of the sociability deficit of the genetically-inbred Balb/c mouse strain
D-serine improves dimensions of the sociability deficit of the genetically-inbred Balb/c mouse strain
复制标题
DOI：
10.1016/j.brainresbull.2010.10.010
复制
发表时间：
2011-01-15
影响因子：
3.8
通讯作者：
Deutsch, Stephen I.
中科院分区：
文献类型：
--
作者：
Jacome, Luis F.;Burket, Jessica A.;Deutsch, Stephen I.
Balb/c小鼠品系表现出社交能力的定量缺陷，并对非竞争性NMDA受体拮抗剂MK-801(地佐西平)行为过敏。D-丝氨酸(560 mg/kg，腹腔注射)是NMDA受体上必需的甘氨酸联合激动剂结合部位的完全激动剂，它增加了Balb/c小鼠在装有封闭的社会刺激小鼠的隔间中花费的时间，并增加了Balb/c小鼠在标准社交装置中探索(嗅探)装有封闭的社会刺激小鼠的倒置杯子的时间。D-丝氨酸对Balb/c小鼠品系社交能力受损的这些影响并不是由于对运动活动的“非特异性”影响：重要的是，在封闭或自由移动的社会刺激小鼠存在的情况下，Balb/c小鼠品系的运动活动减少。这些数据表明，针对性的NMDA受体激动剂干预可以改善Balb/c小鼠品系受损的社交能力。(C)2010 Elsevier Inc.保留所有权利。
The Balb/c mouse strain shows quantitative deficits of sociability and is behaviorally-hypersensitive to MK-801 (dizocilpine), a noncompetitive NMDA receptor antagonist. D-Serine (560 mg/kg, intraperitoneally), a full agonist for the obligatory glycine co-agonist binding site on the NMDA receptor, increased the amount of time Balb/c mice spend in a compartment containing the enclosed social stimulus mouse and the amount of time Balb/c mice spend exploring (sniffing) an inverted cup containing the enclosed social stimulus mouse in a standard sociability apparatus. These effects of D-serine on the impaired sociability of the Balb/c mouse strain were not due to a "nonspecific" effect on locomotor activity: importantly, the locomotor activity of the Balb/c mouse strain decreases in the presence of an enclosed or freely-moving social stimulus mouse. The data suggest that dimensions of the impaired sociability of the Balb/c mouse strain may be improved by targeted NMDA receptor agonist interventions. (c) 2010 Elsevier Inc. All rights reserved.