TRAIL, DR5 and caspase 3-dependent apoptosis in vessels of diseased human temporomandibular joint disc. An immunohistochemical study
TRAIL, DR5 and caspase 3-dependent apoptosis in vessels of diseased human temporomandibular joint disc. An immunohistochemical study
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DOI：
10.4081/ejh.2010.e40
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发表时间：
2010-01-01
影响因子：
2
通讯作者：
Leonardi, R.
中科院分区：
文献类型：
--
作者：
Loreto, C.;Almeida, L. E.;Leonardi, R.
为了评估凋亡参与颞下颌关节（TMJ）退行性椎间盘血管形成的自限性过程，我们评估，通过免疫组织化学，TRAIL，其死亡受体DR 5和caspase 3的检测。采用免疫组化方法检测15个未复位的颞下颌关节盘和4个未复位的颞下颌关节盘中TRAIL及其死亡受体DR 5和caspase 3的表达。这些凋亡分子在新形成的血管受累椎间盘的内膜和中膜层中检测到。总之，血管凋亡激活与ID的颞下颌关节盘可以被视为一个自我限制的过程，试图导致血管退化;以这种方式抑制血管生成的血管可能被证明是一个关键的策略，在限制病理性血管生成，切断血液供应的肿瘤，或通过减少有害的炎症。
To evaluate the apoptosis involvement in the angiogenesis as a self-limiting process in patients with temporomandibular joint (TMJ) degenerated disc vessels, we assessed, by immunohistochemistry, the detection of TRAIL, its death receptor DR5 and caspase 3. TRAIL, its death receptor DR5 and caspase 3 expression were studied by immunohistochemistry in 15 TMJ discs displaced without reduction and in 4 unaffected discs. These apoptosis molecules were detected in the intima and media layers of newly formed vessels affected discs. In conclusion, vessels apoptosis activation in TMJ disc with ID could be regarded as a self-limiting process that try to leads to vessel regression; in this way an inhibition of angiogenic vessels may prove a key strategy in limiting pathological angiogenesis, by cutting off blood supply to tumors, or by reducing harmful inflammation.