Changes in pulmonary function and their correlation with dose-volume parameters in patients undergoing stereotactic body radiotherapy for lung cancer.
Changes in pulmonary function and their correlation with dose-volume parameters in patients undergoing stereotactic body radiotherapy for lung cancer.
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DOI：
10.1093/jrr/rraa131
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发表时间：
2021-03-10
影响因子：
2
通讯作者：
Nagai A
中科院分区：
文献类型：
--
作者：
Takemoto S;Shibamoto Y;Hashizume C;Miyakawa A;Murai T;Yanagi T;Sugie C;Nagai A
肺立体定向体部放射治疗（SBRT）前应评估肺功能下降的程度，尤其是对肺功能较差的患者。本研究的目的是探讨SBRT后肺功能的降低是否可以从辐射剂量-体积参数预测。共对70例接受SBRT的患者的肺功能变化进行了评价。其中原发性肺癌67例，肺转移3例。26例（37%）患者患有慢性阻塞性肺疾病。在SBRT前不久和SBRT后18-24个月进行肺功能检查（PFT）。10例患者的放射性肺炎为2级，1例为3级。平均用力肺活量（FVC）从2.67 L降至2.51 L（P < 0.01），平均第一秒用力呼气量（FEV 1）从1.80 L降至1.72 L（P < 0.01）。计划靶体积（PTV）与FVC的变化相关。FVC百分比预测值的变化与%V5戈伊（接受> 5戈伊的肺体积百分比）和%V40戈伊相关。尽管相关性不显著，但%V20 Gy值最接近预测FVC的降低百分比;%V20 Gy 10%往往与预测FVC降低约10%相关。肺功能差的患者不一定显示每个PFT参数的更大降低。FVC和FEV 1的降低在既往报告的范围内。PTV与FVC降低相关。%V20Gy值最接近预测FVC的下降百分比。
It is desirable to estimate the degree of the decrease in pulmonary function before lung stereotactic body radiation therapy (SBRT) especially for patients with poor pulmonary function. The purpose of this study was to investigate whether decreases in pulmonary function after SBRT may be predicted from radiation dose–volume parameters. A total of 70 patients undergoing SBRT were evaluated for changes in pulmonary function. Of these, 67 had primary lung cancer and 3 had lung metastasis. Twenty-six (37%) patients had chronic obstructive pulmonary disease. Pulmonary function tests (PFTs) were performed shortly before and at 18–24 months after SBRT. Radiation pneumonitis was Grade 2 in 10 patients and Grade 3 in 1. Mean forced vital capacity (FVC) decreased from 2.67 to 2.51 L (P < 0.01) and mean forced expiratory volume in 1 s (FEV1) decreased from 1.80 to 1.72 L (P < 0.01). Planning target volume (PTV) was correlated with changes in FVC. Changes in percent predicted FVC were correlated with %V5Gy (% of lung volume receiving > 5 Gy) and %V40Gy. Although the correlation was not significant, the %V20Gy value was the closest to the percent reduction in predicted FVC; %V20Gy of 10% tended to be associated with ~10% reduction in predicted FVC. Patients with poor pulmonary function did not necessarily show greater decreases in each PFT parameter. Decreases in FVC and FEV1 were within previously reported ranges. PTV was associated with decreases in FVC. The %V20Gy value was closest to the percentage decrease in predicted FVC.
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对医疗统计信息的自由使用的易于使用的软件“ EZR”的调查。
影响因子：
4.8
作者：
Kanda Y
通讯作者：
Kanda Y
影响因子：
51.1
作者：
Chang, Joe Y.;Senan, Suresh;Paul, Marinus A.;Mehran, Reza J.;Louie, Alexander V.;Balter, Peter;Groen, Harry J. M.;McRae, Stephen E.;Widder, Joachim;Feng, Lei;van den Borne, Ben E. E. M.;Munsell, Mark F.;Hurkmans, Coen;Berry, Donald A.;van Werkhoven, Erik;Kresl, John J.;Dingemans, Anne-Marie;Dawood, Omar;Haasbeek, Cornelis J. A.;Carpenter, Larry S.;De Jaeger, Katrien;Komaki, Ritsuko;Slotman, Ben J.;Smit, Egbert F.;Roth, Jack A.
通讯作者：
Roth, Jack A.
影响因子：
2
作者：
Shibamoto Y;Miyakawa A;Otsuka S;Iwata H
通讯作者：
Iwata H
DOI：
10.1016/j.ijrobp.2009.06.091
发表时间：
2010-03-01
影响因子：
7
作者：
Marks, Lawrence B.;Bentzen, Soren M.;Deasy, Joseph O.;Kong, Feng-Ming (Spring);Bradley, Jeffrey D.;Vogelius, Ivan S.;El Naqa, Issam;Hubbs, Jessica L.;Lebesque, Joos V.;Timmerman, Robert D.;Martel, Mary K.;Jackson, Andrew
通讯作者：
Jackson, Andrew
DOI：
10.1016/j.ijrobp.2012.09.016
发表时间：
2013-03-15
影响因子：
7
作者：
Guckenberger, Matthias;Klement, Rainer J.;Grills, Inga S.
通讯作者：
Grills, Inga S.