Prevalence, risk factors, and prognosis of peritoneal metastasis from breast cancer.
Prevalence, risk factors, and prognosis of peritoneal metastasis from breast cancer.
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DOI：
10.1186/s40064-015-1449-x
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Risaliti A
中科院分区：
文献类型：
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作者：
Bertozzi S;Londero AP;Cedolini C;Uzzau A;Seriau L;Bernardi S;Bacchetti S;Pasqual EM;Risaliti A
乳腺癌腹膜转移是一种严重且致命的疾病，文献中仅有限地考虑过。我们的目的是研究乳腺癌腹膜转移的患病率、危险因素和预后。我们回顾性分析了 3096 名被诊断患有浸润性乳腺癌的女性。我们考虑了乳腺癌远处转移的存在和定位，以及可能的危险因素和乳腺癌转移诊断后的生存率。乳腺癌腹膜转移的患病率为 0.7% (22/3096)，相当于 7.6% (22/289) 的女性患有远处转移。此外，乳腺癌腹膜转移的独立危险因素导致诊断时分级高、小叶浸润性组织学以及晚期 T 和 N 分期。与其他转移性女性相比，腹膜转移或脑转移的女性诊断转移后的总生存期较短。乳腺癌腹膜转移并不常见，但也并非罕见，在标准治疗后预后不良。
Peritoneal metastasis from breast cancer is a serious and deadly condition only limited considered in the literature. Our aim was to study prevalence, risk factors, and prognosis of breast cancer peritoneal metastasis. We retrospectively analyzed 3096 women with a diagnosis of invasive breast cancer. We took into consideration presence and localization of breast cancer distant metastasis as well as the possible risk factors and survival from the diagnosis of the breast cancer metastasis. The prevalence of breast cancer peritoneal metastases was 0.7 % (22/3096), representing the 7.6 % (22/289) of women affected by distant metastases. Moreover, independent risk factors for breast cancer peritoneal metastases resulted high grading, lobular invasive histology, and advanced T and N stage at diagnosis. Overall survival after metastasis diagnosis was shorter in women affected by peritoneal metastases or brain metastases in comparison to other metastatic women. Breast cancer peritoneal metastases were uncommon but not rare events with a poor prognosis after standard treatments.