Efficacy of anterior chamber paracentesis and carbogen in treating acute nonarteritic central retinal artery occlusion
Efficacy of anterior chamber paracentesis and carbogen in treating acute nonarteritic central retinal artery occlusion
复制标题
DOI：
10.1016/s0161-6420(95)30758-0
复制
发表时间：
1995-12-01
期刊：
影响因子：
13.7
通讯作者：
Cater, J
中科院分区：
文献类型：
--
作者：
Atebara, NH;Brown, GC;Cater, J
目的：确定前房穿刺术和Carbogen吸入治疗是否急性非动脉炎性视网膜中央动脉阻塞（CRAO）患者的最终视力与未治疗的患者相比有显著差异。在这项回顾性研究中，在Wills眼科医院视网膜血管科就诊的89名患有急性CRAO的连续患者的记录，这些患者接受前房穿刺术和Carbogen治疗，或前房穿刺术或Carbogen疗法。40例患者接受了两种治疗，而49例患者没有接受任何治疗。在治疗前和随后的随访中测量视力。所有在症状发作24小时内就诊的患者均接受治疗，而24小时后就诊的患者大多未接受治疗。结果：经初步视力调整后，分层Wilcoxon分析显示治疗组和未治疗组之间无统计学显著差异（P = 0.87）。两个比例之间的差异的posthoc功率分析表明，该研究有足够的权力（0.80），以检测治疗和未治疗groups.Conclusion之间的10%与25%的改善患者的比例的差异：数据表明，前房穿刺术和Carbogen治疗提供治疗急性非动脉炎性CRAO的好处不大。
Purpose: To determine whether anterior chamber paracentesis and Carbogen inhalation therapy (95% oxygen, 5% carbon dioxide) produce a significant difference in final Visual acuity in eyes with acute nonarteritic central retinal artery occlusion (CRAO), compared with untreated eyes.Methods: in this retrospective study, the records of 89 consecutive patients seen at the Retina Vascular Unit of Wills Eye Hospital with acute CRAO who received either both anterior chamber paracentesis and Carbogen therapy, or neither anterior chamber paracentesis or Carbogen therapy, were reviewed. Forty patients were treated with both therapies, whereas 49 received neither modality. Visual acuities before treatment and at subsequent follow-up visits were measured. All patients seen within 24 hours of the onset of symptoms were treated, whereas most of those seen after 24 hours were not treated,Results: Stratified Wilcoxon analysis showed no statistically significant difference between the treated and untreated groups (P = 0.87) after adjusting for initial vision. A posthoc power analysis for the difference between two proportions showed that the study had adequate power (0.80) to detect a difference of the proportion of improved patients of 10% versus 25% between the treated and untreated groups.Conclusion: The data suggest that anterior chamber paracentesis and Carbogen therapy offer little benefit for treating acute nonarteritic CRAO.