HEALTHY AGING, MEMORY SUBSYSTEMS AND REGIONAL CEREBRAL OXYGEN-CONSUMPTION
HEALTHY AGING, MEMORY SUBSYSTEMS AND REGIONAL CEREBRAL OXYGEN-CONSUMPTION
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DOI：
10.1016/0028-3932(95)00021-t
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发表时间：
1995-07-01
期刊：
影响因子：
2.6
通讯作者：
BARON, JC
中科院分区：
文献类型：
--
作者：
EUSTACHE, F;RIOUX, P;BARON, JC
本研究旨在寻找伴随年龄变化的记忆子系统（根据当前的结构理论定义）和选定大脑区域的静息耗氧量。我们调查了一组年龄在20至68岁之间的受试者样本，并对他们的健康状况进行了严格筛选。我们在同一受试者中应用了一系列神经心理学测试来研究几个记忆子系统，并使用立体定位的高分辨率正电子成像来研究有限数量的大脑结构，这些结构是根据先验假设选择的，以匹配不同的记忆子系统。我们的研究结果显示，在一些测试中，与年龄相关的表现变化显著，与文献一致，包括语义记忆的增加和工作记忆（中央执行系统）以及言语情景和外显记忆的减少。总体脑耗氧量也有与年龄相关的线性下降，在新皮质区和左丘脑区域达到了统计学意义。原始心理测试分数与静息区域氧化代谢之间存在有限数量的显著的、与年龄无关的相关性。与我们目前对记忆功能解剖的理解一致，联想学习分数（言语情景记忆和外显记忆）与左海马和丘脑代谢呈正相关。在联想学习和Brown-Peterson测试中发现的右海马体代谢与表现之间的正相关关系较少被预期，但与最近PET激活研究的结果一致。从这项调查的结果讨论了目前的知识有关神经心理学和神经生物学老化和记忆。
The present study was designed to search for concomitant age-related changes in memory subsystems, defined according to current structural theories, and resting oxygen consumption in selected brain regions. We have investigated a sample of subjects between 20 and 68 years of age and strictly screened for their good health. We applied in the same subjects a battery of neuropsychological tests selected to investigate several memory subsystems, and high-resolution positron imaging with stereotaxic localization to study a purposely limited number of cerebral structures, selected on a priori hypotheses to match the different memory subsystems.Our results showed significant age-related changes in performance on some tests, consistent with the literature, including an increase in semantic memory and a decrease in both working memory (central executive system) and verbal episodic and explicit memory. There was also an age-related linear decrease in global brain oxygen consumption which regionally reached statistical significance for the neocortical areas and the left thalamus. There was a limited number of significant, age-independent correlations between the raw psychometric test scores and resting regional oxidative metabolism. Consistent with our present understanding of the functional anatomy of memory, the Associate Learning scores (verbal episodic and explicit memory) were positively correlated with left hippocampal and thalamic metabolism. The positive relationships found between right hippocampal metabolism and performance in the Associate Learning and the Brown-Peterson tests were less expected but would be consistent with findings from recent PET activation studies. The results from this investigation are discussed in the light of current knowledge concerning the neuropsychology and the neurobiology of both aging and memory.