Asymmetric 1,4-reductions of hindered β-substituted cycloalkenones using catalytic SEGPHOS-ligated CuH
Asymmetric 1,4-reductions of hindered β-substituted cycloalkenones using catalytic SEGPHOS-ligated CuH
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DOI：
10.1021/ol0400185
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发表时间：
2004-04-15
期刊：
影响因子：
5.2
通讯作者：
Lover, AA
中科院分区：
文献类型：
--
作者：
Lipshutz, BH;Servesko, JM;Lover, AA
由非外消旋SEGPHOS配体连接的催化量的铜氢化物的试剂组合在原位导致了一种极具活性的物种，该物种能够在很高的Es中实现共轭环烯酮的不对称硅氢化反应。这种转化的底物与配体之比达到了史无前例的高达275000：1。
The reagent combination of catalytic amounts of copper hydride ligated by a nonracemic SEGPHOS ligand leads in situ to an extremely reactive species capable of effecting asymmetric hydrosilylations of conjugated cyclic enones in very high ees. An unprecedented substrate-to-ligand ratio as high as 275 000:1 for this transformation has been documented.