Medial prefrontal cortex lesions in the female rat affect sexual and maternal behavior and their sequential organization
Medial prefrontal cortex lesions in the female rat affect sexual and maternal behavior and their sequential organization
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DOI：
10.1037/0735-7044.121.3.515
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发表时间：
2007-06-01
影响因子：
1.9
通讯作者：
Fleming, Alison S.
中科院分区：
文献类型：
--
作者：
Afonso, Veronica M.;Sison, Margarette;Fleming, Alison S.
本实验研究了内侧前额叶皮层（mPFC）损伤后雌性大鼠性行为和母性行为的时间序列及其相互关系和与感觉-运动门控反应抑制任务（PPI）成绩的相关性。在兴奋性毒性mPFC（n = 10）或假手术（n = 9）损伤后，对卵巢周期中的性行为进行评分。交配和分娩后，对母体相互作用进行评分，直至幼仔达到产后第10天。卵巢周期恢复后，对雌性大鼠进行PPI检测。与假损伤相比，mPFC损伤损害了接受行为和一些母性行为（例如，幼犬取回，幼犬舔）但不影响其他（例如，筑巢，幼犬吐奶）。病变破坏了时间序列的招标（男性取向的数量，随后，在4秒内，由一个级别的变化）和小狗检索（小狗检索的数量，随后，在5秒内，由另一个检索）。这些顺序行为模式彼此之间以及与PPI之间存在显著相关性。然而，当PPI效应被部分排除时，组间差异不那么强烈，但持续存在。这项研究表明，mPFC操纵影响行动丰富的序列结构，以响应生物相关的刺激。
Temporal sequences of sexual and maternal behaviors in Female rats and their correlation with each other and with performance on a sensory-motor gating response inhibition task assessed by prepulse inhibition (PPI) were investigated following medial prefrontal cortex (mPFC) lesions. Following excitotoxic mPFC (n = 10) or sham (n = 9) lesions, sexual behaviors across the ovarian cycle were scored. After mating and parturition, maternal interactions were scored until pups reached postnatal Day 10. After resumption of the ovarian cycle, the female rats were tested for PPI. Compared with sham lesions, mPFC lesions impaired proceptive behaviors and some maternal behaviors (e.g., pup retrieval, pup licking) but did not affect others (e.g., nest building, pup mouthing). Lesions disrupted temporal sequences of solicitations (number of male orientations followed, within 4 s, by a level change) and pup retrievals (number of pup retrievals followed, within 5 s, by another retrieval). These sequential behavior patterns were significantly correlated with each other and with PPI. However, when PPI effects were partialled out, group differences were less strong, but persisted. This study demonstrated that mPFC manipulations affect actions rich in sequential structure in response to biologically relevant stimuli.