Analysis of antigenic drift in the haemagglutinin molecule of influenza B virus with monoclonal antibodies.
Analysis of antigenic drift in the haemagglutinin molecule of influenza B virus with monoclonal antibodies.
复制标题
用单克隆抗体分析乙型流感病毒血凝素分子的抗原漂移。
DOI：
10.1099/0022-1317-54-2-243
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发表时间：
1981
期刊：
影响因子：
--
通讯作者：
Berton,MT
中科院分区：
文献类型：
--
作者：
Webster,RG;Berton,MT
用单克隆抗体研究了乙型流感病毒血凝素（HA）分子的抗原漂移。抗原漂移发生在所研究的12个不同表位中的每一个，有证据表明，至少有两种抗原可区分的乙型流感病毒株可在流行期间共传播。乙型流感病毒HA抗原变异的频率通常小于1 / 108，约为。比甲型流感病毒低1000倍。用12种不同的单克隆抗体对抗原变异进行血凝抑制（HI）试验表明，抗原决定因子可细分为三个部分重叠的组。用单克隆抗体选择的许多抗原变异与感染后雪貂血清的亲本病毒区分开来，这表明确实发生的大多数变异可能具有流行病学潜力。
Antigenic drift in the haemagglutinin (HA) molecule of influenza B viruses was studied with monoclonal antibodies. Antigenic drift occurred in each of the 12 different epitopes studied and there was evidence that at least two antigenically distinguishable influenza B virus strains can co-circulate during an epidemic. The frequency of antigenic variation in the HA of influenza B viruses was frequently less than 1 in 108 and was approx. 1000-fold below that found in influenza A strains. Haemagglutination inhibition (HI) tests on antigenic variants selected with 12 different monoclonal antibodies suggested that the antigenic determinants could be subdivided into three partially overlapping groups. Many of the antigenic variants selected with monoclonal antibodies were distinguishable from the parental virus with post-infection ferret sera, suggesting that the majority of the variants that do occur could have epidemiological potential.