EVIDENCE FOR JOINT GENIC CONTROL OF SPONTANEOUS MUTATION AND GENETIC-RECOMBINATION DURING MITOSIS IN SACCHAROMYCES
EVIDENCE FOR JOINT GENIC CONTROL OF SPONTANEOUS MUTATION AND GENETIC-RECOMBINATION DURING MITOSIS IN SACCHAROMYCES
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DOI：
10.1007/bf00695392
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发表时间：
1977-01-01
期刊：
影响因子：
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通讯作者：
ESPOSITO, MS
中科院分区：
文献类型：
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作者：
GOLIN, JE;ESPOSITO, MS
为了探索酵母菌自发突变和重组的联合基因控制，建立了一种检测酵母菌有丝分裂和/或减数分裂过程中自发突变增强或减少的方法。通过该技术回收的半显性突变子rem 1 -1在有丝分裂期间表现出增强的自发突变、基因内重组和基因间重组。rem 1 -1纯合的二倍体表现出正常水平的减数分裂基因内和基因间重组和降低的子囊孢子活力。
A procedure for detection of mutants exhibiting either enhanced or reduced spontaneous mutation during mitosis and/or meiosis was developed to probe the joint genic control of spontaneous mutation and recombination in yeast. A semi-dominant mutator, rem1-1, recovered by this technique, exhibits enhanced spontaneous mutation, intragenic recombination and intergenic recombination during mitosis. Diploids homozygous for rem1-1 exhibit normal levels of meiotic intragenic and intergenic recombination and diminished ascospore viability.