Myeloperoxidase-generated oxidants and atherosclerosis
Myeloperoxidase-generated oxidants and atherosclerosis
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DOI：
10.1016/s0891-5849(00)00229-x
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发表时间：
2000-06-15
影响因子：
7.4
通讯作者：
Hazen, SL
中科院分区：
文献类型：
--
作者：
Podrez, EA;Abu-Soud, HM;Hazen, SL
动脉粥样硬化是一种慢性炎症过程，动脉壁内的氧化损伤与疾病的发病机制有关。单核巨噬细胞是一种能够产生多种氧化物种的炎性细胞，是动脉损伤的早期组成部分。它们的正常功能包括通过调节产生可扩散的自由基物种、活性氧或氮物种以及HOC1(次氯酸)来防御和监视宿主。然而，在某些情况下，过量的这些氧化物种会压倒局部的抗氧化剂防御，导致氧化应激和氧化组织损伤，这些过程与动脉粥样硬化的发病机制有关。本文综述了髓过氧化物酶(MPO)催化的氧化反应，髓过氧化物酶是一种由活化的吞噬细胞分泌的丰富的血红素蛋白，存在于人类动脉粥样硬化病变中。在过去的几年里，大量的证据证明了这一点。MPO是心血管疾病发展过程中蛋白质和脂蛋白氧化的途径之一。多种不同的MPO产物在人类动脉粥样硬化病变中富含，从人类动脉粥样硬化病变中回收的低密度脂蛋白。然而，这些MPO在体内催化的反应的生物学后果仍然不清楚。在这里，我们讨论了在体内发生MPO催化的氧化反应的证据，以及MPO在正常宿主防御和炎症性疾病(如动脉粥样硬化)中所起的潜在作用。(C)2000年爱思唯尔科学公司。
Atherosclerosis is a chronic inflammatory process where oxidative damage within the artery wall is implicated in the pathogenesis of the disease. Mononuclear phagocytes, an inflammatory cell capable of generating a variety of oxidizing species, are early components of arterial lesions. Their normal functions include host defense and surveillance through regulated generation of diffusible radical species, reactive oxygen or nitrogen species, and HOC1 (hypochlorous acid). However, under certain circumstances an excess of these oxidizing species can overwhelm local antioxidant defenses and lead to oxidant stress and oxidative tissue injury, processes implicated in the pathogenesis of atherosclerosis. This review focuses on oxidation reactions catalyzed by myeloperoxidase (MPO), an abundant heme protein secreted from activated phagocytes which is present in human atherosclerotic lesions. Over the past several years, significant evidence has accrued demonstrating that. MPO is one pathway for protein and lipoprotein oxidation during the evolution of cardiovascular disease. Multiple distinct products of MPO are enriched in human atherosclerotic lesions and LDL recovered from human atheroma. However, the biological consequences of these MPO-catalyzed reactions in vivo are still unclear. Here we discuss evidence for the occurrence of MPO-catalyzed oxidation reactions in vivo and the potential role MPO plays in both normal host defenses and inflammatory diseases like atherosclerosis. (C) 2000 Elsevier Science Inc.