Properties of statistical tests of neutrality for DNA polymorphism data.
Properties of statistical tests of neutrality for DNA polymorphism data.
复制标题
DOI：
--
复制
发表时间：
1995-09
期刊：
影响因子：
3.3
通讯作者：
K. Simonsen;G. Churchill;C. Aquadro
中科院分区：
文献类型：
--
作者：
K. Simonsen;G. Churchill;C. Aquadro
研究了一类基于分子多态性数据的统计检验，以确定尺寸和功率特性。该类包括Tajima的D统计量以及Fu和Li提出的D* 和F* 检验。一种新的方法来构建这些测试的临界值。模拟结果表明，田岛的测试一般是最强大的选择性扫描，人口瓶颈，人口细分的替代假设，在这一类的测试。然而，即使是田岛的测试可以检测到选择性扫描或瓶颈，只有当它已经发生在一个特定的时间间隔在最近的过去或人口细分，只有当它已经持续了很长一段时间。为了最大限度地对抗这里研究的特定替代方案，最好是测序更多的等位基因而不是更多的位点。
A class of statistical tests based on molecular polymorphism data is studied to determine size and power properties. The class includes Tajima's D statistic as well as the D* and F* tests proposed by Fu and Li. A new method of constructing critical values for these tests is described. Simulations indicate that Tajima's test is generally most powerful against the alternative hypotheses of selective sweep, population bottleneck, and population subdivision, among tests within this class. However, even Tajima's test can detect a selective sweep or bottleneck only if it has occurred within a specific interval of time in the recent past or population subdivision only when it has persisted for a very long time. For greatest power against the particular alternatives studied here, it is better to sequence more alleles than more sites.