Distinct Reward Properties are Encoded via Corticostriatal Interactions.
Distinct Reward Properties are Encoded via Corticostriatal Interactions.
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DOI：
10.1038/srep20093
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发表时间：
2016-02-02
影响因子：
4.6
通讯作者：
Delgado MR
中科院分区：
文献类型：
--
作者：
Smith DV;Rigney AE;Delgado MR
纹状体是大脑中处理奖励的关键区域。然而，理解纹状体和奖励之间的联系是一个挑战，因为奖励是由多种属性组成的。值得注意的是，情感属性调节情绪，而信息属性有助于获得未来的奖励。我们通过在两个独立的猜谜游戏中强调情感和信息奖励属性来解决这个问题。我们发现，这两种奖励特性在纹状体的一个亚区伏隔核内都引起了激活。纹状体对信息性而非情感性奖励属性的反应预测了随后利用信息获得金钱奖励的行为。我们假设纹状体的激活可能是必要的，但不足以编码不同的奖励特性。为了研究这种可能性，我们研究了在皮质纹状体相互作用中，情感和信息奖励属性是否被不同地编码。引人注目的是，我们发现纹状体与腹外侧前额叶皮层表现出可分离的连接模式，情感奖励特性的连接增加，信息奖励特性的连接减少。我们的研究结果表明，情感和信息奖励属性是通过皮质纹状体相互作用编码的。这些发现强调了皮质纹状体系统如何促进奖励处理，潜在地推进了纹状体激活与行为联系的模型。
The striatum serves as a critical brain region for reward processing. Yet, understanding the link between striatum and reward presents a challenge because rewards are composed of multiple properties. Notably, affective properties modulate emotion while informative properties help obtain future rewards. We approached this problem by emphasizing affective and informative reward properties within two independent guessing games. We found that both reward properties evoked activation within the nucleus accumbens, a subregion of the striatum. Striatal responses to informative, but not affective, reward properties predicted subsequent utilization of information for obtaining monetary reward. We hypothesized that activation of the striatum may be necessary but not sufficient to encode distinct reward properties. To investigate this possibility, we examined whether affective and informative reward properties were differentially encoded in corticostriatal interactions. Strikingly, we found that the striatum exhibited dissociable connectivity patterns with the ventrolateral prefrontal cortex, with increasing connectivity for affective reward properties and decreasing connectivity for informative reward properties. Our results demonstrate that affective and informative reward properties are encoded via corticostriatal interactions. These findings highlight how corticostriatal systems contribute to reward processing, potentially advancing models linking striatal activation to behavior.