Correlation analysis between immune-related genes and cell infiltration revealed prostate cancer immunotherapy biomarkers linked to T cells gamma delta.
Correlation analysis between immune-related genes and cell infiltration revealed prostate cancer immunotherapy biomarkers linked to T cells gamma delta.
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免疫相关基因和细胞浸润之间的相关性分析揭示了与 T 细胞 γ δ 相关的前列腺癌免疫治疗生物标志物。
DOI：
10.1038/s41598-023-28475-6
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发表时间：
2023-02-11
影响因子：
4.6
通讯作者：
中科院分区：
文献类型：
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作者：
前列腺癌是一种预后不良的泌尿系统恶性肿瘤。免疫相关基因与前列腺癌的免疫浸润有关，但它们在免疫原性PCa中的作用尚不清楚。我们评估了22种免疫细胞在PCa中的浸润模式以及免疫相关差异表达基因（IDEGs）与它们的关系。87个IDEG参与细胞外基质和肿瘤微环境之间的相互作用。包括7个IDEG（SLPI、DES、IAPP、NPY、ISG 15、PLA 2G 2A和HLA-DMB）的模型显示出良好的预测能力。SLPI表达与γ δ T细胞浸润水平呈正相关。此外，PCa在巨噬细胞M1（18.07%）和活化的树突状细胞（17.64%）中具有高浸润水平。IDEGs与免疫细胞浸润之间的相关性分析表明，PCa免疫治疗生物标志物可能与T细胞γ δ密切相关。
Prostate cancer (PCa) is a urological malignancy with poor prognosis. Immune-related genes are associated with immune infiltration in prostate cancer, but their role in immunogenic PCa is less well understood. We assessed the infiltration patterns of 22 immune cells in PCa and the relationship of immune-related differentially expressed genes (IDEGs) with them. The 87 IDEGs are involved in the interaction between the extracellular matrix and the tumor microenvironment. The model, including seven IDEGs (SLPI, DES, IAPP, NPY, ISG15, PLA2G2A, and HLA-DMB), showed a good predictive power. The SLPI expression is positively correlated with the infiltration level of T cells gamma delta. In addition, PCa has high infiltration levels in Macrophages M1 (18.07%) and Dendritic cells activated (17.64%). The correlation analysis between IDEGs and immune cell infiltration suggested that PCa immunotherapy biomarkers may be closely related to T cells gamma delta.
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影响因子：
11.2
作者：
Dieli F;Vermijlen D;Fulfaro F;Caccamo N;Meraviglia S;Cicero G;Roberts A;Buccheri S;D'Asaro M;Gebbia N;Salerno A;Eberl M;Hayday AC
通讯作者：
Hayday AC
DOI：
10.1158/1078-0432.ccr-16-2821
发表时间：
2017-08-15
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Lee JM;Lee MH;Garon E;Goldman JW;Salehi-Rad R;Baratelli FE;Schaue D;Wang G;Rosen F;Yanagawa J;Walser TC;Lin Y;Park SJ;Adams S;Marincola FM;Tumeh PC;Abtin F;Suh R;Reckamp KL;Lee G;Wallace WD;Lee S;Zeng G;Elashoff DA;Sharma S;Dubinett SM
通讯作者：
Dubinett SM
影响因子：
5.2
作者：
Ferraro S;Bussetti M;Bassani N;Rossi RS;Incarbone GP;Bianchi F;Maggioni M;Runza L;Ceriotti F;Panteghini M
通讯作者：
Panteghini M
影响因子：
158.5
作者：
Kantoff, Philip W.;Higano, Celestia S.;Young, J.
通讯作者：
Young, J.
影响因子：
1.2
作者：
Delma, Mohamed Islam
通讯作者：
Delma, Mohamed Islam