Vitamin D Deficiency Is Associated With the Severity of Radiation-Induced Proctitis in Cancer Patients
Vitamin D Deficiency Is Associated With the Severity of Radiation-Induced Proctitis in Cancer Patients
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DOI：
10.1016/j.ijrobp.2015.02.011
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发表时间：
2015-07-01
影响因子：
7
通讯作者：
Hemati, Simin
中科院分区：
文献类型：
--
作者：
Ghorbanzadeh-Moghaddam, Amir;Gholamrezaei, Ali;Hemati, Simin
目的：正常组织的放射损伤是癌症患者放射治疗的常见并发症。考虑到维生素D在粘膜屏障止血和炎症反应中的作用，我们研究了维生素D缺乏是否与癌症患者放射性急性直肠炎的严重程度相关。方法和材料：这项前瞻性观察性研究是在癌症患者盆腔放疗中进行的。放射治疗前测定血清25-羟维生素D浓度。维生素D缺乏定义为25-羟基维生素D浓度
Purpose: Radiation-induced injury to normal tissues is a common complication of radiation therapy in cancer patients. Considering the role of vitamin D in mucosal barrier hemostasis and inflammatory responses, we investigated whether vitamin D deficiency is associated with the severity of radiation-induced acute proctitis in cancer patients.Methods and Materials: This prospective observational study was conducted in cancer patients referred for pelvic radiation therapy. Serum concentration of 25-hydroxyvitamin D was measured before radiation therapy. Vitamin D deficiency was defined as 25-hydroxyvitamin D concentrations of