DIARRHEA AMONG AFRICAN CHILDREN BORN TO HUMAN IMMUNODEFICIENCY VIRUS-1-INFECTED MOTHERS - CLINICAL, MICROBIOLOGIC AND EPIDEMIOLOGIC FEATURES
DIARRHEA AMONG AFRICAN CHILDREN BORN TO HUMAN IMMUNODEFICIENCY VIRUS-1-INFECTED MOTHERS - CLINICAL, MICROBIOLOGIC AND EPIDEMIOLOGIC FEATURES
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DOI：
10.1097/00006454-199211120-00002
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发表时间：
1992-12-01
影响因子：
3.6
通讯作者：
GRIFFIN, PM
中科院分区：
文献类型：
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作者：
PAVIA, AT;LONG, EG;GRIFFIN, PM
腹泻和体重减轻是儿童和成人1型人类免疫缺陷病毒（HIV-1）感染的共同特征，特别是在发展中国家。我们前瞻性地研究了559名儿童的腹泻发作，年龄在10至15个月，参加了围产期HIV-1感染的纵向研究在金沙萨，扎伊尔。感染HIV-1的儿童腹泻发作更频繁，更可能出现发热或中度或重度脱水，并出现持续性或致命性腹泻。9例HIV- 1阳性腹泻患儿中，3例肠粘附因子阳性大肠埃希菌，而74例HIV-1阴性腹泻患儿中有5例肠粘附因子阳性大肠埃希菌（P = 0.04）;无其他病原体与HIV-1感染相关。在逻辑回归模型中，腹泻与儿童的HIV-1感染、母亲的中度或重度营养不良和获得性免疫缺陷综合征症状显著相关。扎伊尔围产期感染艾滋病毒的儿童腹泻比未感染的儿童更严重，并与母亲营养不良和晚期疾病有关。
Diarrhea and weight loss are common features of pediatric and adult human immunodeficiency type 1 (HIV-1) infection, particularly in developing countries. We studied prospectively episodes of diarrhea in 559 children, ages 10 to 15 months, participating in a longitudinal study of perinatal HIV-1 infection in Kinshasa, Zaire. Children with HIV-1 infection had more frequent episodes of diarrhea and were more likely to present with fever or moderate or severe dehydration and to have persistent or fatal diarrhea. Of 9 HIV- 1-positive infants with diarrhea, 3 had enteroadherence factor-positive Escherichia coli, compared with 5 of 74 HIV-1-negative children with diarrhea (P = 0.04); no other pathogen was associated with HIV-1 infection. In a logistic regression model diarrhea was significantly associated with HIV-1 infection in the child, moderate or severe malnutrition and symptoms of acquired immunodeficiency syndrome in the mother. Diarhea among children with perinatal HIV infection in Zaire is more severe than among uninfected children and is associated with malnutrition and advanced disease in the mother.