Temporomandibular disorder is associated with a serotonin transporter gene polymorphism in the Japanese population
Temporomandibular disorder is associated with a serotonin transporter gene polymorphism in the Japanese population
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DOI：
10.1186/1751-0759-1-3
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发表时间：
2007-01-01
影响因子：
2.1
通讯作者：
Narita, Masaaki
中科院分区：
文献类型：
--
作者：
Ojima, Kiyomi;Watanabe, Nagaoki;Narita, Masaaki
目的：最近的遗传学研究表明，阿托宁相关的遗传多态性与以功能性躯体症状为特征的多种疾病有关，包括慢性疲劳综合征、肠易激综合征和经前焦虑障碍。方法：我们通过筛选36例颞下颌关节紊乱病（TMD）患者的基因组DNA，研究了三种阿托宁相关的遗传多态性。长等位基因的显著增加通过基因型分析和等位基因分析，在TMD患者中发现与对照相比，结论：TMD的发病可能与涉及神经系统的遗传因素有关。
Aims: Recent genetic studies have linked serotonin-related genetic polymorphisms with diverse disorders characterized by functional somatic symptoms, including chronic fatigue syndrome, irritable bowel syndrome, and premenstrual dysphoric disorder.Methods: We investigated three serotonin-related genetic polymorphisms by screening genomic DNA of 36 temporomandibular disorder (TMD) patients.Results: A significant increase of longer alleles (l and xl) was found in the TMD patients compared to the controls both by the genotype-wise and the allele-wise analyses (both p < 0.01 by chi(2) test and Fisher's exact test).Conclusion: Genetic factors that involve the serotonergic system may play a role in the pathogenesis of TMD.