Synthesis of the ABC ring system of azaspiracid. 1. Effect of D ring truncation on bis-spirocyclization
Synthesis of the ABC ring system of azaspiracid. 1. Effect of D ring truncation on bis-spirocyclization
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DOI：
10.1021/ol026033w
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发表时间：
2002-06-27
期刊：
影响因子：
5.2
通讯作者：
Graves, DE
中科院分区：
文献类型：
--
作者：
Carter, RG;Bourland, TC;Graves, DE
已完成具有截短D环的螺环化前体的合成。随后的双螺环化诱导形成等量的天然transoidal 10R，13R双螺环和其cisoidal 10R，13S差向异构体在一个明显的药物控制的过程。
[GRAPHICS]Synthesis of a spirocyclization precursor with a truncated D ring has been accomplished. Subsequent bis-spirocyclization induced the formation of equal amounts of the natural transoidal 10R,13R bis-spirocycle and its cisoidal 10R,13S epimer under an apparent thermodynamically controlled process.