Synovial and inflammatory diseases in childhood: role of new imaging modalities in the assessment of patients with juvenile idiopathic arthritis
Synovial and inflammatory diseases in childhood: role of new imaging modalities in the assessment of patients with juvenile idiopathic arthritis
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DOI：
10.1007/s00247-010-1612-z
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发表时间：
2010-06-01
影响因子：
2.3
通讯作者：
Toma, Paolo
中科院分区：
文献类型：
--
作者：
Damasio, Maria Beatrice;Malattia, Clara;Toma, Paolo
幼年特发性关节炎(JIA)是一组以慢性炎症过程为特征的异质性疾病，主要以滑膜为靶点。持续性滑膜炎与骨关节损伤的风险增加有关。随着对JIA的有效结构修改治疗的出现，有可能显著减少甚至完全防止结构损伤和相关的功能障碍。为了预防腐蚀性疾病，早期抑制炎症的趋势将重点从传统的可检测到的结构损伤转移到早期关节损伤的最轻微痕迹上，并推动了对替代成像技术的需求，以更灵敏地检测疾病活动和损伤的早期迹象。在这方面，MRI和US在关节炎关节的评估中发挥着越来越大的作用。本文将综述用于风湿病儿童调查的影像技术的现状和最新的重要进展，简要讨论传统的放射学，特别是MRI和US。在这个成像技术进步的时代，了解现有成像技术的相对价值对于优化JIA儿童的治疗是必要的。
Juvenile idiopathic arthritis (JIA) represents a group of heterogeneous diseases characterized by a chronic inflammatory process primarily targeting the synovial membrane. A persistent synovitis is associated with an increased risk of osteocartilaginous damage.With the advent of effective structure-modifying treatment for JIA, it may be possible to significantly reduce or even completely prevent structural damage and associated functional disability. The trend towards early suppression of inflammation, in order to prevent erosive disease, shifts the emphasis away from conventional radiographic detectable structural damage to the slightest traces of early joint damage, and drives the need for alternative imaging techniques more sensitive in detecting early signs of disease activity and damage. In this regard MRI and US are playing an increasing role in the evaluation of arthritic joints.This article will review the key aspects of the current status and recent important advances of imaging techniques available to investigate the child with rheumatic disease, briefly discussing conventional radiography, and particularly focusing on MRI and US. In this era of advancing imaging technology, knowledge of the relative values of available imaging techniques is necessary to optimize the management of children with JIA.