Trends in prenatal prescription opioid use among Medicaid beneficiaries in Wisconsin, 2010-2019.
Trends in prenatal prescription opioid use among Medicaid beneficiaries in Wisconsin, 2010-2019.
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2010-2019 年威斯康星州医疗补助受益人产前处方阿片类药物使用趋势。
DOI：
10.1038/s41372-024-01954-y
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发表时间：
2024
期刊：
影响因子：
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通讯作者：
Berger,LawrenceM
中科院分区：
文献类型：
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作者：
Ehrenthal,DeborahB;Wang,Yi;Pac,Jessica;Durrance,ChristinePiette;Kirby,RussellS;Berger,LawrenceM
研究设计队列研究所有（262，284）威斯康星州医疗保险活产婴儿2010-2019。产前暴露被分类为镇痛药、短期和慢性（90天以上），以及用于治疗阿片类药物使用障碍（MOUD）的药物。我们描述了整体和分层的时间趋势，并使用线性概率模型与相互作用的条款，以测试其significance.ResultWe发现42,437（16.2%）婴儿与产前暴露，大多数（90.5%）反映镇痛阿片类药物。从2010年到2019年，总体风险敞口下降了12.8个百分点（95%CI = 12.1-13.1）。在孕产妇人口群体中以及在农村和城市环境中都观察到了减少，尽管程度不同。有一个小的减少慢性镇痛剂的暴露和并发MOUD.ConclusionBroad和持续下降的产前处方阿片类药物暴露发生在十年中，婴儿慢性暴露的百分比变化不大。
ObjectiveTo examine changes in prenatal opioid prescription exposure following new guidelines and policies.Study designCohort study of all (262,284) Wisconsin Medicaid-insured live births 2010–2019. Prenatal exposures were classified as analgesic, short term, and chronic (90+ days), and medications used to treat opioid use disorder (MOUD). We describe overall and stratified temporal trends and used linear probability models with interaction terms to test their significance.ResultWe found 42,437 (16.2%) infants with prenatal exposure; most (90.5%) reflected analgesic opioids. From 2010 to 2019, overall exposure declined 12.8 percentage points (95% CI = 12.1–13.1). Reductions were observed across maternal demographic groups and in both rural and urban settings, though the extent varied. There was a small reduction in chronic analgesic exposure and a concurrent increase in MOUD.ConclusionBroad and sustained declines in prenatal prescription opioid exposure occurred over the decade, with little change in the percentage of infants chronically exposed.