Sumoylation and regulation of cardiac gene expression.
Sumoylation and regulation of cardiac gene expression.
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DOI：
10.1161/circresaha.110.220491
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发表时间：
2010-07-09
影响因子：
20.1
通讯作者：
Schwartz RJ
中科院分区：
文献类型：
--
作者：
Wang J;Schwartz RJ
相扑修饰是一种翻译后修饰过程，相扑蛋白通过酶促的级联反应与靶蛋白发生可逆的共价偶联。自1996年发现相扑-1基因以来，相扑通路因其在细胞周期进程、表观遗传调控、信号转导、DNA复制/修复等一系列重要生物学活动中的作用以及在癌症发生、转移、神经退行性疾病和颅面部缺陷等人类发病机制中的潜在作用而受到越来越多的关注。相扑通路在调节致心基因活性、发育和/或紊乱方面的作用才刚刚出现。我们的综述是基于最近的进展，强调心脏基因活性在心脏发育和疾病中的调节通过相扑结合途径。
Sumoylation is a post-translational modification process in which SUMO proteins are covalently and reversibly conjugated to their targets via enzymatic cascade reactions. Since the discovery of SUMO-1 in 1996, the SUMO pathway has garnered increased attention due to its role in a number of important biological activities such as cell cycle progression, epigenetic modulation, signal transduction, and DNA replication/repair, as well as its potential implication in human pathogenesis such as in cancer development and metastasis, neurodegenerative disorders and craniofacial defects. The role of the SUMO pathway in regulating cardiogenic gene activity, development and/or disorders is just emerging. Our review is based on recent advances that highlight the regulation of cardiac gene activity in cardiac development and disease by the SUMO conjugation pathway.