Growth and development of term children born with low birth weight: effects of genetic and environmental factors.
Growth and development of term children born with low birth weight: effects of genetic and environmental factors.
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低出生体重足月儿的生长发育：遗传和环境因素的影响。
DOI：
10.1016/s0022-3476(98)70180-5
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发表时间：
1998
期刊：
影响因子：
--
通讯作者：
Dietz,WH
中科院分区：
文献类型：
--
作者：
Strauss,RS;Dietz,WH
目的探讨胎儿宫内发育迟缓（IUGR）在控制环境和遗传因素的情况下对儿童生长发育的影响。在出生时和7岁时，对整个国家围产期合作项目人群中出生的IUGR和非IUGR足月儿（“人群队列”）的体重、身长和智商进行评估。为了控制遗传和环境因素，还比较了220对性别相近的足月同胞对的生长发育情况，其中一对同胞出生时患有IUGR，另一对同胞出生时没有IUGR结果在7岁时，IUGR婴儿的身高和体重比非IUGR婴儿的身高和体重低约0.5SD（年龄别体重：p < 0.001，年龄别身高：p < 0.001）。在全国围产期协作项目人群中，IUGR组的IQ（p < 0.001）和Bender-Gestalt（p < 0.001）评分显著低于非IUGR组。有和没有IUGR的兄弟姐妹之间的智商或Bender-Gestalt分数没有显着差异。然而，与IUGR和头围大缺陷的兄弟姐妹表现出降低智商（p < 0.05）和Bender-Gestalt（p < 0.05）scores.ConclusionLong-term生长缺陷与IUGR似乎在很大程度上独立于产前或产后的环境因素。IUGR对智力和运动发育的影响很小，除非与头围的大缺陷有关。（J Pediatr 1998;133：67-72）
ObjectiveTo evaluate the role of intrauterine growth retardation (IUGR) on childhood growth and development, controlling for environmental and genetic factors.MethodsWomen and infants enrolled in the National Collaborative Perinatal Project were analyzed. Weight, length, and IQ were assessed at birth and at 7 years in the entire National Collaborative Perinatal Project population in term infants born with and without IUGR (“population cohort”). To control for genetic and environmental factors, growth and development were also compared in 220 similar-sex term sibling pairs in which one sibling was born with IUGR and one was born without IUGR (“sibling cohort”).ResultsAt 7 years of age heights and weights of infants born with IUGR remained ~0.5 SD less than infants born without IUGR (weight-for-age: p < 0.001, height-for-age: p < 0.001). In the entire National Collaborative Perinatal Project population, IQ (p < 0.001) and Bender-Gestalt (p < 0.001) scores were significantly lower in infants born with IUGR compared with those in infants born without IUGR. There were no significant differences in IQ or Bender-Gestalt scores between siblings born with and without IUGR. However, siblings with IUGR and large deficits in head circumference demonstrated both decreased IQ (p < 0.05) and Bender-Gestalt (p < 0.05) scores.ConclusionLong-term growth deficits associated with IUGR appear largely independent of prenatal or postnatal environmental factors. IUGR had little impact on intelligence and motor development except when associated with large deficits in head circumference. (J Pediatr 1998;133:67-72)
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DOI：
10.1016/0301-0104(86)85003-0
发表时间：
1986
期刊：
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DOI：
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发表时间：
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影响因子：
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DOI：
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发表时间：
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DOI：
10.1016/0005-2728(87)90147-2
发表时间：
1987
期刊：
Biochimica et Biophysica Acta
影响因子：
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