Source of drinking water at home and site-specific cancer incidence in Washington County, Maryland.
Source of drinking water at home and site-specific cancer incidence in Washington County, Maryland.
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马里兰州华盛顿县的家庭饮用水源和特定地点的癌症发病率。
DOI：
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发表时间：
1981
影响因子：
5
通讯作者：
G. Comstock
中科院分区：
文献类型：
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作者：
J. R. Wilkins;G. Comstock
进行了一项非同期前瞻性研究，以调查水氯化的有机化学副产品与人类癌症风险之间的假设关系。近 31,000 名研究对象的重要记录和非官方人口普查数据被用来计算特定县人口中特定性别和特定地点的癌症发病率。研究人员检查了研究人群的年龄、社会经济状况、吸烟史、家庭饮用水来源以及其他个人特征与癌症发病率的关系。饮用水源变量由三个历史队列组成，每个队列的特点是不同程度地接触氯仿和其他氯化副产物。与有饮用未氯化地下水历史的人群相比，在家中供应氯化地表水的饮用水人群中男性膀胱癌和女性肝癌的发病率几乎高出两倍。然而，差异并不具有统计学意义。一项补充死亡率研究还表明，氯化水与肝癌和尿路癌存在关联。华盛顿县的研究结果表明，需要对具有不同氯化和未氯化饮用水接触史的个人进行进一步研究。
A nonconcurrent prospective study was conducted to investigate the postulated relationship between organic chemical by-products of water chlorination and risk of human cancer. Vital records and nonofficial census data available for each of nearly 31,000 study subjects were used to compute selected sex- and site-specific cancer incidence rates in a well-defined county population. Age, socioeconomic status, smoking history, source of drinking water at home, and other individual characteristics of the study population were examined in relation to the cancer rates. The drinking water source variable consisted of three historical cohorts, each distinguished by a different degree of exposure to chloroform and other chlorination byproducts. Incidence rates for cancer of the bladder among men and for cancer of the liver among women were nearly twofold higher in the drinking water cohort that had been supplied chlorinated surface water at home when compared to the cohort with a history of consumption of unchlorinated ground water. The differences, however, were not statistically significant. A complementary mortality study also suggested an association of chlorinated water with cancer of the liver and urinary tract. The findings in Washington County indicate the need for further studies of individuals with different histories of exposure to chlorinated and unchlorinated drinking water.