4D printing of highly printable and shape morphing hydrogels composed of alginate and methylcellulose
4D printing of highly printable and shape morphing hydrogels composed of alginate and methylcellulose
复制标题
由海藻酸盐和甲基纤维素组成的高度可打印和变形水凝胶的 4D 打印
DOI：
10.1016/j.matdes.2021.109699
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发表时间：
2021-04-20
影响因子：
8.4
通讯作者：
Wang, Min
中科院分区：
文献类型：
--
作者：
Lai, Jiahui;Ye, Xinliang;Wang, Min
可膨胀/可收缩水凝胶的4D打印已被视为制造各种生物医学应用的动态结构的一种有吸引力的方法。然而，当使用基于微挤压的3D打印机时，由于水凝胶的印刷适性相对较差以及印刷图案的表面粗糙度较高，因此精确的水凝胶结构的4D打印仍然具有高度的挑战性。本研究通过海藻酸盐(Alg)和甲基纤维素(MC)的共混，研究了一种可用于4D打印的高度可打印和形状变形的水凝胶。优化后的Alg/MC水凝胶具有优良的流变性、挤出性和印刷结构的形状保真度。可打印的AlG/MC水凝胶被4D打印成一系列图案化的2D结构，通过战略性地控制垂直于图案化条带取向的网络密度梯度，这些图案化的2D结构具有各向异性的刚性和膨胀行为。通过控制条带的间距和角度，这些2D结构在浸泡在氯化钙溶液中后可以转变为各种规定的简单3D形态(例如卷管和螺旋)和复杂的3D形态(例如双螺旋和花朵)。这种形状变形的AlG/MC水凝胶具有良好的印刷性能，在组织工程、生物医学设备和软机器人领域越来越需要这种精细的水凝胶图案的4D打印具有很高的潜力。由爱思唯尔有限公司出版。这是一篇在CC by License(http://creativecommons.org/licenses/by/4.0/).下的开放获取文章
4D printing of swellable/shrinkable hydrogels has been viewed as an appealing approach for fabricating dynamic structures for various biomedical applications. However, 4D printing of precise hydrogel structures is still highly challenging due to the relatively poor printability of hydrogels and high surface roughness of printed patterns, when micro extrusion-based 3D printers are used. In this study, a highly printable and shape morphing hydrogel was investigated for 4D printing by blending alginate (Alg) and methylcellulose (MC). The optimized Alg/MC hydrogel exhibited excellent rheological properties, extrudability and shape fidelity of printed structures. The printable Alg/MC hydrogel was 4D printed into a series of patterned 2D architectures which were encoded with anisotropic stiffness and swelling behaviors by strategically controlling the network density gradients vertical to the orientation of the patterned strips. By controlling the strip interspacing and angle, these 2D architectures could transform into various prescribed simple 3D morphologies (e.g., tube-curling and helix) and complex 3D morphologies (e.g., double helix and flowers) after immersion in a calcium chloride solution. This shape morphing Alg/MC hydrogel with excellent printability has high potential for 4D printing of delicate hydrogel patterns, which are increasingly needed in the tissue engineering, biomedical device and soft robotics fields.(C)& nbsp;2021 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).