Proportion of tuberculosis transmission that takes place in households in a high-incidence area
Proportion of tuberculosis transmission that takes place in households in a high-incidence area
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DOI：
10.1016/s0140-6736(03)15332-9
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发表时间：
2004-01-17
期刊：
影响因子：
168.9
通讯作者：
van Helden, PD
中科院分区：
文献类型：
--
作者：
Verver, S;Warren, RM;van Helden, PD
与结核病患者有家庭接触的人中的感染率很高。这些信息经常指导积极的病例发现。我们分析了来自南非开普敦邻近郊区Ravensmead和Uitsig的765名结核病患者的结核分枝杆菌DNA指纹。在129个家庭中，DNA指纹可用于一个以上的病人，我们确定了313名患者，其中145人（46%）的指纹模式匹配的另一个家庭成员。社区内发生在家庭内的传播比例为19%，因此，在该高发区，结核病传播主要发生在家庭外。
The prevalence of infection among household contacts of people with tuberculosis is high. This information frequently guides active case finding. We analysed DNA fingerprints of Mycobacterium tuberculosis from 765 tuberculosis patients in Ravensmead and Uitsig, adjacent suburbs of Cape Town, South Africa. In 129 households in which DNA fingerprints were available for more than one patient, we identified 313 patients, of whom 145 (46%) had a fingerprint pattern matching that of another member of the household. The proportion of transmission in the community that took place in the household was 19%, and therefore, in this high-incidence area, tuberculosis transmission occurs mainly outside the household.