Virtual ligand screening combined with NMR to identify Dvl PDZ domain inhibitors targeting the Wnt signaling.
Virtual ligand screening combined with NMR to identify Dvl PDZ domain inhibitors targeting the Wnt signaling.
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DOI：
10.1007/978-1-62703-008-3_2
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Zheng, Jie J
中科院分区：
文献类型：
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作者：
Shan, Jufang;Zheng, Jie J
虚拟配体筛选（VLS）是一种强有力的技术，以确定潜在的命中目标，并提高命中率。在这里，我们描述了我们如何使用这种技术与NMR 15N HSQC实验相结合，以获得小分子结合的PDZ结构域的Dvl靶向Wnt信号传导途径。
Virtual ligand screening (VLS) is a powerful technique to identify potential hits of targets and to increase hit rates. Here, we describe how we used this technique combined with NMR 15N HSQC experiments to obtain small molecules that bind to the PDZ domain of Dvl targeting the Wnt signaling pathway.