Extractive Spectrophotometric Determination of Quetiapine Fumarate in Pharmaceuticals and Spiked Human Urine
Extractive Spectrophotometric Determination of Quetiapine Fumarate in Pharmaceuticals and Spiked Human Urine
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DOI：
10.5562/cca1770
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发表时间：
2012-04
影响因子：
0.3
通讯作者：
N. Rajendraprasad;K. Basavaiah;K. Vinay
中科院分区：
文献类型：
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作者：
N. Rajendraprasad;K. Basavaiah;K. Vinay
建立了一种简单、灵敏、选择性的提取分光光度法测定原料药、片剂和人尿中富马酸喹硫平（QTF）的方法。该方法是基于药物的碱性氮（QTF）与染料喹啉黄（QY）在醋酸盐-盐酸缓冲液（pH为2.56）中形成氯仿可萃取的黄色离子对络合物。形成的离子对络合物在420 nm处吸收最大。在2.5 ~ 25 μ g mL（-1）的浓度范围内服从比尔定律，表观摩尔吸收率为2.02 × 10(4) L mol(-1) cm（-1）。还报道了桑德尔灵敏度、检出限（LOD）和定量值。通过Job连续变分法确定离子对的组成为1:1 （QTF:QY）。该方法可用于原料药、片剂和加标尿液中QTF的测定，无干扰。(doi: 10.5562 / cca1770)
A simple, sensitive and selective extractive spectrophotometric method for the determination of quetiapine fumarate (QTF) in bulk drug, tablets and spiked human urine sample is described. The method is based on the formation of a chloroform extractable yellow ion-pair complex between basic nitrogen of the drug (QTF) and the dye quinoline yellow (QY) in acetate-hydrochloride buffer (pH 2.56) medium. The formed ion-pair complex exhibited an absorption maximum at 420 nm. Beer's law is obeyed over the concentration range 2.5-25 mu g mL(-1) with an apparent molar absorptivity value of 2.02 x 10(4) L mol(-1) cm(-1). The Sandell sensitivity, limits of detection (LOD) and quantification values are also reported. The composition of the ion-pair was established by Job's continuous variations method and it was found to be 1:1 (QTF:QY). The proposed method was successfully applied for the determination of QTF in bulk drug, tablets and spiked human urine without any interference. (doi: 10.5562/cca1770)