Assessment of polychlorinated biphenyl congeners, thyroid stimulating hormone, and free thyroxine among New York State anglers
Assessment of polychlorinated biphenyl congeners, thyroid stimulating hormone, and free thyroxine among New York State anglers
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DOI：
10.1016/j.ijheh.2009.04.005
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发表时间：
2009-11-01
影响因子：
6
通讯作者：
Kostyniak, Paul J.
中科院分区：
文献类型：
--
作者：
Bloom, Michael S.;Vena, John E.;Kostyniak, Paul J.
实验文献表明，多氯联苯（PCBs）改变甲状腺功能，但对人群非职业或急性接触的研究结果不确定。这项研究考虑了多氯联苯和甲状腺功能生物标志物之间的关联，特别选择的子样本的参与者从纽约州垂钓者队列研究，与假设生成的目标。在1995年至1997年期间，38名受试者捐献了血液标本并完成了问卷调查。使用GC-ECD分析了血清中的77种多氯联苯同源物、乙型六氯环己烷、DDE、六氯苯、灭蚁灵、氧氯噻嗪和反式九甲草胺，以及脂质成分、促甲状腺激素（TSH）和游离甲状腺素（FT 4）。先验，SLIM的所有77个测量的PCB同系物，27个单独的PCB同系物与甲状腺影响的文献证据，其总和，DDE，和六氯苯被选为潜在的预测甲状腺功能。年龄、体重指数、吸烟、性别和甲状腺相关药物的使用被认为是重要的协变量。校正log总血脂后，log PCB IUPAC #s 153（r = 0.33）、170（r = 0.38）、171 + 156（r = 0.36）和180（r = 0.35）与FT 4存在显著（P < 0.05）双变量相关性;但未观察到log TSH。使用前向逐步选择程序和混杂因素评估算法，log PCB #170是血清FT 4的显著阳性预测因子（β = 1.55 95%CI 0.04-3.07），校正了平均中心log PCB #187和log血清总脂质。这种关联可以通过PCB #170、其羟基化代谢物4 '-OH-PCB 172或其他相关但未考虑的化合物与血清甲状腺结合蛋白的竞争性结合来解释。然而，由于使用竞争性类似物测定法进行游离激素测定，存在偏倚。不能排除随机误差或不受控制的混杂。这项研究的结果表明，安大略湖运动鱼消费者可能包括高风险人群PCB相关的甲状腺功能改变，并保证更大的验证性调查。(C)2009年Elsevier GmbH。All rights reserved.
Experimental literature suggests that polychlorinated biphenyls (PCBs) alter thyroid function however Studies of non-occupational or acute exposures in human populations have presented equivocal results. This study considered associations between PCBs and thyroid function biomarkers in a specially selected subsample of participants from the New York State Angler Cohort Study, with the goal of hypotheses generation. Between 1995 and 1997, 38 subjects donated a blood specimen and completed a questionnaire. Sera were analyzed for 77 PCB congeners, beta-HCH, DDE, HCB, mirex, oxychlordane, and trans-nonachlor using GC-ECD, as well as for lipids components, thyroid stimulating hormone (TSH) and free thyroxine (FT4). A priori, the SLIM of all 77 measured PCB congeners, 27 individual PCB congeners with literature evidence for thyroid effects, their sum, DDE, and HCB were chosen as potential predictors for thyroid function. Age, body mass index, cigarette smoking, gender, and use of thyroid relevant medications were considered as important covariates. Adjusted for log total serum lipids, significant (P < 0.05) bivariate correlations were demonstrated for log PCB IUPAC #s 153 (r = 0.33), 170 (r = 0.38), 171 + 156 (r = 0.36), and 180 (r = 0.35) with FT4; however none were observed for log TSH. Using a forward stepwise selection procedure and confounder evaluation algorithm, log PCB #170 was a significant positive predictor of serum FT4 (beta = 1.55 95%CI 0.04-3.07), adjusted for mean centered log PCB #187 and log serum total lipids. This association may be explained by competitive binding to serum thyroid binding proteins by PCB #170, its hydroxylated metabolite 4'-OH-PCB 172, or other related but unconsidered compounds. However, bias due to the use of a competitive analog assay for free hormone measurement. random error, or uncontrolled Confounding cannot be excluded. The results of this study suggest that Lake Ontario sportfish consumers may comprise a high risk population for PCB related thyroid function alteration and warrant a larger confirmatory investigation. (C) 2009 Elsevier GmbH. All rights reserved.