SURF4 has oncogenic potential in NIH3T3 cells
SURF4 has oncogenic potential in NIH3T3 cells
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DOI：
10.1016/j.bbrc.2018.05.116
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发表时间：
2018-07-07
影响因子：
3.1
通讯作者：
Lee, Dongjun
中科院分区：
文献类型：
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作者：
Kim, Jayoung;Hong, Chae Mi;Lee, Dongjun
SURF4位于Surfeit基因簇中，编码一个保守的完整膜蛋白，该蛋白含有多个假定的跨膜区域。然而，SURF4的生理作用尚未确定。我们发现SURF4在一些人类癌症患者的肿瘤组织中表现出异常扩增和表达增加。过表达SURF4导致细胞增殖、迁移和维持不依赖锚定的生长。此外，过表达SURF4的NIH3T3细胞诱导小鼠肿瘤生长。综上所述，我们的研究结果表明，SURF4在体外具有诱导细胞转化和细胞迁移的潜力，在体内具有致癌转化能力。(C) 2018年作者。Elsevier Inc.出版。
SURF4, which is located in the Surfeit gene cluster, encodes for a conserved integral membrane protein containing multiple putative transmembrane regions. However, the physiological role of SURF4 has not been determined. We found that SURF4 demonstrated aberrant amplification and increased expression in the tumor tissues of several human cancer patients. Overexpression of SURF4 led to increased cell proliferation, migration, and maintenance of anchorage-independent growth. In addition, NIH3T3 cells overexpressing SURF4 induced tumor growth in the mice. Collectively, our findings demonstrate that SURF4 has the potential for inducing cellular transformation and cell migration in vitro and has oncogenic transformation ability in vivo. (C) 2018 The Authors. Published by Elsevier Inc.