A specialized channel for encoding auditory transients in the magnocellular division of the human medial geniculate nucleus.
A specialized channel for encoding auditory transients in the magnocellular division of the human medial geniculate nucleus.
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DOI：
10.1097/wnr.0000000000001830
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发表时间：
2022-10-12
期刊：
影响因子：
1.7
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中科院分区：
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我们测试的假设，存在一个广义的大细胞系统在大脑中优化的时间处理。在视觉系统中，外侧膝状体核（LGN）中的大细胞层被瞬变强烈激活并迅速适应。然而，很少有人知道可能类似的大细胞分裂的医学膝状体核（MGN），在丘脑的听觉中继。我们测量了11名受试者被动地听持续和短暂的非语言的声音，使用功能磁共振成像（fMRI）的MGN的功能反应。我们观察到，体素在腹内侧部分的MGN，对应于大细胞分裂，表现出强大的偏好，瞬态的声音，一致的跨科目，而其余的MGN没有持续和瞬态的声音之间的区别。我们的结论是，在MGN的大细胞神经元平行的大细胞神经元在其视觉对应，LGN，并构成一个专门用于编码听觉动力学的信息流。
We test the hypothesis that there exists a generalized magnocellular system in the brain optimized for temporal processing. In the visual system, it is well known that the magnocellular layers in the lateral geniculate nucleus (LGN) are strongly activated by transients and quickly habituate. However, little is known about the perhaps analogous magnocellular division of the medical geniculate nucleus (MGN), the auditory relay in the thalamus. We measured the functional responses of the MGN in 11 subjects who passively listened to sustained and transient non-linguistic sounds, using functional MRI (fMRI). We observed that voxels in the ventromedial portion of the MGN, corresponding to the magnocellular division, exhibited a robust preference to transient sounds, consistently across subjects, whereas the remainder of the MGN did not discriminate between sustained and transient sounds. We conclude that the magnocellular neurons in the MGN parallel the magnocellular neurons in its visual counterpart, LGN, and constitute an information stream specialized for encoding auditory dynamics.