Elevated levels of collagenase and prostaglandin e2 from synovium associated with chronic lyme arthritis
Elevated levels of collagenase and prostaglandin e2 from synovium associated with chronic lyme arthritis
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滑膜中胶原酶和前列腺素 e2 水平升高与慢性莱姆关节炎相关
DOI：
10.1002/art.1780230511
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发表时间：
1980
影响因子：
--
通讯作者：
S. Malawista
中科院分区：
文献类型：
--
作者：
A. Steere;C. Brinckerhoff;Denis J. Miller;H. Drinker;E. D. Harris;S. Malawista
一名患有慢性莱姆关节炎和X线检查显示骨侵蚀的患者接受了滑膜切除术;发现含有小淋巴细胞聚集物的增生性滑膜（血管翳）粘附在侵蚀的软骨和骨上。在8天的组织培养，滑膜细胞产生大量的胶原酶和前列腺素E2，但只有低水平的神经和酸性蛋白酶。滑膜中67%的淋巴细胞是T细胞，19%是B细胞。试图在滑膜细胞中鉴定试剂/抗原是不成功的。因此，这个病人的滑膜，其疾病似乎是蜱传播的，类似于类风湿性关节炎。这一发现进一步支持了一个假设，即许多可能的因素，包括感染性因素，触发了滑膜中的一个共同途径，导致关节破坏。
A patient with chronic Lyme arthritis and roentgenographic evidence of bony erosion underwent a synovectomy; proliferative synovium (pannus), containing aggreagates of small lymphocytes, was found adherent to eroded cartilage and bone. During 8 days in tissue culture, the synovial cells produced large amounts of collagenase and prostaglandin E2, but only low levels of both neurtral and acid proteinases. Sixty-seven percent of the lymphocytes from the synovium were T cells; 19% were B cells. Attempts to identify agent/antigen in the synovial cells were unsuccessful. Thus, the synovium of this patient, whose disease appears to be tick-transmitted, resembles that of rheumatoid arthritis. This finding further supports the hypothesis that many possible agents, including infectious ones, trigger a common pathway in synovium, which leads to joint destruction.