Is telomere length one of the determinants of reproductive life span?
Is telomere length one of the determinants of reproductive life span?
复制标题
DOI：
10.1007/s00404-004-0690-2
复制
发表时间：
2005-07-01
影响因子：
2.6
通讯作者：
Tukun, Ajlan
中科院分区：
文献类型：
--
作者：
Aydos, Sena E.;Elhan, Atilla H.;Tukun, Ajlan
生殖寿命最终终止的机制尚未解决。通常认为最重要的因素是卵巢卵泡储备。在子宫内时期的卵巢中，决定原始卵泡数量的主要因素是有丝分裂能力以及迁移到性腺嵴的原始生殖细胞的数量。端粒长度是决定细胞有丝分裂次数的因素之一。同龄健康女性端粒长度的差异反映了子宫内原始生殖细胞端粒的差异。据推测，具有长端粒的女性在生命之初其原始生殖细胞就具有长端粒。因此，这些细胞应该比短细胞有更多的有丝分裂和卵巢中更多的卵泡数量。本研究的目的是分析生殖寿命与端粒长度的关系。采用纤维FISH技术测量了37名50岁女性志愿者的端粒长度。研究发现生殖寿命与端粒长度呈正相关。
The mechanism of final cessation of the reproductive life span has not been solved yet. It is generally assumed that the most important factor is ovarian follicular reserve. In ovaries at intrauterine period, a major factor that determines the number of the primordial follicle is the mitotic ability as well as the number of primordial germ cells, which migrate to gonadal ridge. The telomere length is one factor that determines the number of mitosis of the cell. The differences between the telomere lengths of same aged healthy women reflect the difference of the telomeres of the primordial germ cells at the intrauterine period. Women with long telomeres supposedly have had their primordial germ cells at the beginning of life with long telomeres. So, these cells should have had more mitotic division and more follicle numbers in the ovaries than the short ones. The aim of this study was to analyse the relation of the reproductive life span and telomere length. The telomere lengths of 37 women volunteers aged 50 years were measured by fiber FISH technique. A positive correlation was found between reproductive life span and the telomere length.