Mechanisms of vascular calcification in chronic kidney disease
Mechanisms of vascular calcification in chronic kidney disease
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DOI：
10.1681/asn.2007080854
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发表时间：
2008-02-01
影响因子：
13.6
通讯作者：
Chen, Neal X.
中科院分区：
文献类型：
--
作者：
Moe, Sharon M.;Chen, Neal X.
血管钙化在慢性肾脏疾病中很常见，并与发病率和死亡率增加有关。其机制是多因素的，尚不完全清楚。慢性肾脏疾病患者有血管钙化的危险，因为多种危险因素诱导血管平滑肌细胞转变为软骨细胞或成骨细胞样细胞；骨代谢异常导致全身钙磷负荷过高；低水平的循环和局部产生的抑制剂；肾排泄受损；以及目前的治疗方法。这些因素共同增加了血管钙化的风险并使其管理复杂化。
Vascular calcification is common in chronic kidney disease and associated with increased morbidity and mortality. Its mechanism is multifactorial and incompletely understood. Patients with chronic kidney disease are at risk for vascular calcification because of multiple risk factors that induce vascular smooth muscle cells to change into a chondrocyte or osteoblast-like cell; high total body burden of calcium and phosphorus due to abnormal bone metabolism; low levels of circulating and locally produced inhibitors; impaired renal excretion; and current therapies. Together these factors increase risk and complicate the management of vascular calcification.