NUMERICAL SIMULATION OF HUMAN SYSTEMIC ARTERIAL HEMODYNAMICS BASED ON A TRANSMISSION LINE MODEL AND RECURSIVE ALGORITHM
NUMERICAL SIMULATION OF HUMAN SYSTEMIC ARTERIAL HEMODYNAMICS BASED ON A TRANSMISSION LINE MODEL AND RECURSIVE ALGORITHM
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DOI：
10.1142/s0219519411004587
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发表时间：
2012-03-01
影响因子：
0.8
通讯作者：
Liu, Xinghua
中科院分区：
文献类型：
--
作者：
He, Wei;Xiao, Hanguang;Liu, Xinghua
提出了一种新的递归算法来计算人体动脉树的输入阻抗，并利用55段传输线模型来模拟人体动脉的血流动力学。在输入阻抗的计算中，动脉树的结构被表示为一个单链表。用一个无穷小常数代替0 Hz频率，同时计算输入阻抗的直流和交流部分。该算法可以方便地求出动脉树上任意点的输入阻抗。输入阻抗的计算结果与实验数据和其他模型的计算结果雅阁。此外，还比较了动脉顺应性、长度、内径和壁厚对升主动脉输入阻抗的影响。结果表明，升主动脉的输入阻抗在不同参数下表现出明显不同的特性。最后计算各动脉段的血压和血流波形并进行三维显示。分别通过改变杨氏模量和相位差讨论了动脉弹性和粘度的变化。仿真结果表明，动脉树的血压和流量波形准确地反映了生理病理变化的主要特征，证明了该模型的有效性。
A novel recursive algorithm was proposed to calculate the input impedance of human systemic arterial tree, and to simulate the human systemic arterial hemodynamics with an 55 segment transmission line model. In calculation of input impedance, the structure of the arterial tree was expressed as a single linked list. An infinitesimal constant was used to replace 0 Hz frequency to calculate the DC and AC part of input impedance simultaneously. The input impedance at any point of the arterial tree can obtain easily by the proposed recursive algorithm. The results of input impedance are in accord with experimental data and other models' results. In addition, some comparisons were conducted about the effects of arterial compliance, length, internal radius and wall thickness on the input impedance of ascending aorta. The results showed input impedances of ascending aorta displayed significantly different characteristics for different kinds of parameters. Finally, the blood pressure and flow waveforms of all arterial segments were calculated and displayed in 3D. The arterial elasticity and viscosity were discussed by changing the Young's modulus and the phase difference, respectively. The simulation results showed that the blood pressure and flow waveforms of the arterial tree reflected accurately the main characteristic features of physiopathological changes, which demonstrated the effectiveness of the proposed model.