ENDOSCOPIC EVALUATION OF THE EFFECTS OF ASPIRIN, BUFFERED ASPIRIN, AND ENTERIC-COATED ASPIRIN ON GASTRIC AND DUODENAL MUCOSA
ENDOSCOPIC EVALUATION OF THE EFFECTS OF ASPIRIN, BUFFERED ASPIRIN, AND ENTERIC-COATED ASPIRIN ON GASTRIC AND DUODENAL MUCOSA
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DOI：
10.1056/nejm198007173030305
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发表时间：
1980-01-01
影响因子：
158.5
通讯作者：
NELSON, RS
中科院分区：
文献类型：
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作者：
LANZA, FL;ROYER, GL;NELSON, RS
阿司匹林对胃粘膜的损伤作用已通过内窥镜检查123456和粪便失血研究得到充分证明。7，8由于阿司匹林在治疗类风湿性疾病和其他疼痛性肌肉骨骼疾病中的价值毋庸置疑，因此已开发了各种缓冲和肠溶阿司匹林化合物，试图避免这一严重问题。我们的研究有两个目的：通过内窥镜技术以受控的前瞻性方式确定缓冲剂或肠溶包衣是否有效地改善阿司匹林治疗的这种主要副作用;并同时观察胃粘膜中观察到的变化是否与阿司匹林治疗的副作用有关。
THE damaging effect of aspirin on the gastric mucosa has been well documented by endoscopy123456and by studies of fecal blood loss.7,8Because of the unquestioned value of aspirin in the therapy of rheumatoid diseases and other painful musculoskeletal disorders, various buffered and enteric-coated aspirin compounds have been developed in an attempt to circumvent this serious problem. Our study had two purposes: to determine by an endoscopic technique in a controlled prospective manner whether buffering or enteric coating was effective in ameliorating this major side effect of aspirin therapy; and to observe concurrently whether the changes seen in the gastric . . .