6-HYDROXYDOPAMINE LESIONS OF OLFACTORY TUBERCLES AND CAUDATE NUCLEI - EFFECT ON AMPHETAMINE-INDUCED STEREOTYPED BEHAVIOR IN RATS
6-HYDROXYDOPAMINE LESIONS OF OLFACTORY TUBERCLES AND CAUDATE NUCLEI - EFFECT ON AMPHETAMINE-INDUCED STEREOTYPED BEHAVIOR IN RATS
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DOI：
10.1016/0006-8993(74)90888-9
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发表时间：
1974-01-01
期刊：
影响因子：
2.9
通讯作者：
AGHAJANIAN, GK
中科院分区：
文献类型：
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作者：
ASHER, IM;AGHAJANIAN, GK
安非他明诱导的大鼠刻板行为已被用作精神病的动物模型。许多证据表明，这种行为是由安非他明对中枢神经系统多巴胺的作用介导的。有两种不同的多巴胺上升途径（即黑质-纹状体和中脑边缘）。试图确定这两种途径中的哪一种介导安非他明诱导的刻板印象一直没有定论。为了澄清这个问题，在大鼠两个通路的前脑末端区域中进行了6-羟基多巴胺损伤，并观察了动物对随后给药的d-苯丙胺和阿扑吗啡的反应。然后通过组织荧光显微镜分析大脑，以确定多巴胺耗尽区域的边界。结果表明，安非他明诱导的刻板行为是介导的多巴胺投射到头的尾状核。中脑边缘多巴胺通路似乎并不是安非他明诱导的刻板症所必需的。
Amphetamine-induced stereotyped behavior in rats has been used as an animal model of psychosis. Much evidence has indicated that this behavior is mediated by an effect of amphetamine on CNS dopamine. There are two distinct ascending dopamine pathways (i.e.nigro-striatal and mesolimbic). Attempts to determine which of these two pathways mediates amphetamine-induced stereotypy have been inconclusive. In an effort to clarify this question 6-hydroxydopamine lesions were made in the forebrain terminal areas of the two pathways in rats and the response of the animals to the subsequent administration ofd-amphetamine and apomorphine observed. The brains were then analyzed by histofluorescence microscopy to determine the boundaries of dopamine depleted areas. The results indicate that amphetamine-induced stereotyped behavior is mediated by the dopamine projection to the head of the caudate nucleus. The mesolimbic dopamine pathways does not appear to be necessary for amphetamine-induced stereotypy.