Combined application of MRS and DWI can effectively predict cell proliferation and assess the grade of glioma: A prospective study
Combined application of MRS and DWI can effectively predict cell proliferation and assess the grade of glioma: A prospective study
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MRS与DWI联合应用可有效预测细胞增殖并评估胶质瘤分级：一项前瞻性研究
DOI：
10.1016/j.jocn.2020.11.030
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发表时间：
2021-01-07
影响因子：
2
通讯作者：
Ma, Hui
中科院分区：
文献类型：
--
作者：
Hu, Xvlei;Xue, Meifeng;Ma, Hui
为了评价磁共振波谱和弥散加权成像在预测胶质瘤细胞增殖和分级诊断中的联合应用价值，我们前瞻性地收集了MRS的Cho/Cr、Cho/NAA、Cr/NAA和肿瘤实质的ADC(T)、对侧镜像脑组织ADC(ADC(H))、RADC(radc=ADC(T)/ADC(H))。根据术后病理将患者分为LGG组和HGG组，比较两组患者年龄、性别、Ki67、MRS、DWI的差异。接下来，我们分析了MRS、DWI和Ki67之间的相关性。在此基础上，评价MRS、DWI及MRS联合DWI(MRS+DWI)对胶质瘤分级诊断的敏感性和特异性。LGG组与HGG组Ki67、Cho/Cr、Cho/NAA、CrNAA、ADC值、RADC值比较差异有统计学意义(P分别为0.000、0.000、0.000、0.008、0.000、0.000)。从ROC曲线、曲线下面积、灵敏度和特异度分别为(0.901，86.7%，85.7%)，(0.876，80.0%，82.1%)，(0.704，63.3%，71.4%)，(0.862，82.1%，83.3%，83.3%)，(0.820，75.0%，76.7%)，(0.920%，0.920%)，86.7%、89.3%)。Fiser线性判别函数结果表明：Y-1=-20.447+3.46.X-1+17.141.X-2，Y-2=-19.415+4.828.X-1+14.543.X-2。我们的研究表明，MRS和DWI可以在术前有效地预测细胞增殖。MRS结合弥散加权成像可进一步提高对脑胶质瘤分级的敏感性和特异性。(C)2020年由爱思唯尔有限公司出版。
In order to assess combined application of MRS and DWI for prediction cell proliferation and grade diagnosis of glioma, We prospectively collected the Cho/Cr, Cho/NAA, Cr/NAA of MRS and tumor parenchyma ADC (ADC(T)), contralateral mirror brain tissue ADC (ADC(H)), rADC (rADC = ADC(T)/ADC(H)). According to postoperative pathology, the patients were divided into two groups: LGG group and HGG group, compared differences of age, gender, Ki67, MRS, DWI between two groups. Next, we analyzed the correlation between MRS, DWI and Ki67. On this basis, the sensitivity and specificity of MRS, DWI and MRS combined with DWI (MRS + DWI) in diagnosis of glioma grade were evaluated. The differences of Ki67, Cho/Cr, Cho/NAA, Cr/NAA, ADC(T), rADC between LGG group and HGG group were statistically significant (p = 0.000, 0.000, 0.000, 0.008, 0.000, and 0.000 respectively). From ROC curve, area under the curve (AUC), sensitivity and specificity of Cho/Cr, Cho/NAA, Cr/NAA, ADC(T), rADC, PRE (MRS + DWI) were (0.901, 86.7%, 85.7%), (0.876, 80.0%, 82.1%), (0.704, 63.3%, 71.4%), (0.862, 82.1%, 83.3%), (0.820, 75.0%, 76.7%), (0.920, 86.7%, 89.3%), respectively. Fisher's linear discriminant functions results suggest: Y-1 = -20.447 + 3.46.X-1 + 17.141.X-2 (LGG), Y-2 = -19.415 + 4.828.X-1 + 14.543.X-2 (HGG). Our study suggested that MRS and DWI can effectively predict cell proliferation preoperative. MRS combined with DWI can further improve sensitivity and specificity in assessing the grade of glioma. (C) 2020 Published by Elsevier Ltd.