Alcohol elimination in Native American Mission Indians: an investigation of interindividual variation.
Alcohol elimination in Native American Mission Indians: an investigation of interindividual variation.
复制标题
美国原住民宣教印第安人的戒酒：个体差异的调查。
DOI：
10.1111/j.1530-0277.1996.tb01105.x
复制
发表时间：
1996
期刊：
影响因子：
--
通讯作者：
Ehlers,CL
中科院分区：
文献类型：
--
作者：
Wall,TL;Garcia-Andrade,C;Thomasson,HR;Cole,M;Ehlers,CL
美洲原住民中酗酒和酒精依赖的高流行率可能是由这一人群中独特的环境和遗传因素造成的。可能影响酒精中毒发展的一个因素是酒精代谢的变异性。为了确定导致美洲原住民饮酒率差异的因素，这项研究评估了年龄在18岁到25岁之间的健康的南加州传教士印第安人。每个人在∼900AM吃完低脂早餐并禁食一夜后，喝了一剂酒精，0.56g/kg的体积溶液，相当于体重的20%。于饮用前及饮用后15、30、60、90、120、150分钟分别测定血液中酒精浓度。酒精清除率由血液酒精浓度-时间曲线的伪线性斜率计算。通过多元回归分析确定估计的身体水分、最近饮酒史、最近吸烟史、ADH2和ADH3基因座的多态、酗酒家族史和美洲原住民血统对酒精清除率的影响。估计的身体水分在酒精清除率的差异中占了很大比例。携带ADH2*3等位基因的受试者(n=6)比仅携带ADH2*1等位基因的受试者(n=33)排出酒精的速度更快，这一趋势也没有显著意义。鉴于美洲原住民中酒精中毒和与酒精相关的健康问题的高发，这项研究的结果表明，美洲原住民人群中酒精代谢和酒精代谢酶基因类型的评估值得进一步研究。
The high prevalence of alcohol abuse and alcohol dependence among Native Americans may be mediated by unique environmental and genetic factors in this population. One factor that may influence the development of alcoholism is variability in alcohol metabolism. To determine factors that contribute to differences in alcohol elimination rates within a Native American population, this study evaluated healthy southern California Mission Indian men between the ages of 18 and 25 years. Each man drank a dose of alcohol, 0.56 g/kg of body weight as a 20% by volume solution, at ∼900 AM after eating a low‐fat breakfast and having fasted overnight. The drink was consumed within 7 min, and the concentrations of alcohol in blood were determined before and at 15, 30, 60, 90,120, and 150 min after beverage ingestion. Rates of alcohol elimination were calculated from the pseudolinear slope of the blood alcohol versus time curve. The influences of estimated body water, recent drinking history, recent smoking history, polymorphism at the ADH2 and ADH3 loci, family history of alcoholism, and percentage Native American heritage on alcohol elimination rate were determined using multiple regression analyses. Estimated body water accounted for a significant proportion of the variance in alcohol elimination rate. There was also a nonsignificant trend for subjects with anADH2*3 allele (n = 6) to have faster rates of alcohol elimination than those with ADH2*1 alleles only (n = 33). Given the high prevalence of alcoholism and alcohol‐related health problems among Native Americans, the results from this study suggest that evaluation of alcohol metabolism and genotypes of the alcohol‐metabolizing enzymes in Native American populations merits further study.