Collagen VI Encodes Antimicrobial Activity: Novel Innate Host Defense Properties of the Extracellular Matrix
Collagen VI Encodes Antimicrobial Activity: Novel Innate Host Defense Properties of the Extracellular Matrix
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DOI：
10.1159/000335239
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发表时间：
2012-01-01
影响因子：
5.3
通讯作者：
Morgelin, Matthias
中科院分区：
文献类型：
--
作者：
Abdillahi, Suado M.;Balvanovic, Selma;Morgelin, Matthias
VI 型胶原蛋白是气道中的上皮下细胞外基质成分，也是口腔病原体的粘附基质 [Bober 等人：J Innate lmmun 2010；2:160-166]。在这里，我们报告说，VI 型胶原蛋白通过在生理条件下破坏膜，对 A、C 和 G 组链球菌表现出剂量依赖性抗菌活性。这些数据揭示了宿主先天防御中细胞外基质先前未被认识的方面。版权所有 (C) 20125。Karger AG，巴塞尔
Collagen type VI is a subepithelial extracellular matrix component in airways and an adhesive substrate for oral pathogens [Bober et al.: J Innate lmmun 2010;2:160-166]. Here, we report that collagen VI displays a dose-dependent antimicrobial activity against group A, C, and G streptococci by membrane disruption in physiological conditions. The data disclose previously unrecognized aspects of the extracellular matrix in innate host defense. Copyright (C) 20125. Karger AG, Basel