Identification of cellular activation mechanisms associated with salivary secretion.
Identification of cellular activation mechanisms associated with salivary secretion.
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DOI：
10.1146/annurev.ph.48.030186.000451
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发表时间：
1986
影响因子：
18.2
通讯作者：
J. W. Putney
中科院分区：
文献类型：
--
作者：
J. W. Putney
近年来，我们对唾液腺中受体信号传导机制的理解有了相当大的进展。存在两种受体途径，一种涉及cAMP，其主要调节酶分泌，另一种涉及PIP2的水解，其调节Ca2+动员，随后，单价离子通量可能在完整腺体中的离子和水分泌中很重要。Ca 2+的动员是由内部Ca 2+的释放和Ca 2+从细胞外间隙进入引起的。Ca2+释放的信号似乎是（1，4，5）IP3，其为PIP2水解的水溶性产物之一。控制钙进入的机制尚不清楚，但推测比比皆是。PIP2的水解还产生DG，其在激活特定蛋白激酶C激酶中具有信使作用。在调节酶分泌中，C激酶以一些尚未表征的方式与Ca 2+动员相互作用。
In recent years, our understanding of receptor-signalling mechanisms in the salivary glands has advanced considerably. Two receptor pathways exist, one involving cAMP, which primarily regulates enzyme secretion, and another involving the hydrolysis of PIP2, which regulates Ca2+ mobilization and, subsequently, monovalent ion fluxes probably important in ion and water secretion in the intact gland. Mobilization of Ca2+ results from both the release of internal Ca2+, and from Ca2+ entry from the extracellular space. The signal for Ca2+ release appears to be (1,4,5)IP3, one of the water soluble products of PIP2 hydrolysis. The mechanism controlling Ca entry is not understood, but speculation abounds. Hydrolysis of PIP2 also produces DG, which has a messenger role in activating a specific protein kinase, the C kinase. The C kinase interacts with Ca2+ mobilization in some as yet uncharacterized way in regulating enzyme secretion.