Simple Tool for Adding Solid Catalysts without Contamination by Oxygen or Moisture
Simple Tool for Adding Solid Catalysts without Contamination by Oxygen or Moisture
复制标题
添加固体催化剂且不受氧气或水分污染的简单工具
DOI：
10.1016/j.cattod.2021.06.006
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发表时间：
2022
期刊：
影响因子：
5.3
通讯作者：
Kohei Torikai
中科院分区：
文献类型：
--
作者：
Khamid U. Khodjaniyazov;Yohei Joh;Kohei Torikai
尽管催化剂负载是有机和无机催化反应中的第一个关键步骤之一，但迄今为止尚未经常讨论或改进。特别地，当将固体催化剂加入到对氧和水分敏感的反应混合物中时，需要仔细调整工艺以确保惰性气氛（在氮气或氩气下）。尽管手套箱如今被认为是一种通用的解决方案，但它仍然存在未解决的问题，例如高成本、高空间消耗、难以控制温度以及由于手套而导致的操作困难。在此，我们报告了最近开发的一种简单装置，该装置能够在不打开反应容器的情况下添加固体。这种固体添加漏斗大大提高了产率（从微量到64%）和我们原来的糖基化反应的再现性。
Even though catalyst loading is one of the first crucial steps in organic and inorganic catalytic reactions, it has not been frequently discussed or improved to date. In particular, when a solid catalyst is added to an oxygen- and moisture-sensitive reaction mixture, a carefully tuned process to ensure an inert atmosphere (under nitrogen or argon) is required. Although gloveboxes are nowadays considered to be a universal solution, it is still associated with unsolved problems, such as high cost, high space consumption, difficult temperature control, and handling difficulties on account of the gloves. Herein, we report a recently developed simple apparatus that enables the addition of a solid without opening the reaction vessel. This solid-addition funnel drastically improved the yield (from trace to 64%) and the reproducibility of our original glycosylation reaction.