U-Shaped Association Between Duration of Sports Activities and Mortality: Copenhagen City Heart Study
U-Shaped Association Between Duration of Sports Activities and Mortality: Copenhagen City Heart Study
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DOI：
10.1016/j.mayocp.2021.05.028
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发表时间：
2021-12-01
影响因子：
8.9
通讯作者：
Marott, Jacob Louis
中科院分区：
文献类型：
--
作者：
Schnohr, Peter;O'Keefe, James H.;Marott, Jacob Louis
目的：探讨每周余暇体育活动时间与全因死亡的关系。研究方法：作为前瞻性哥本哈根城市心脏研究的一部分，8697名健康成年人完成了一份关于休闲体育活动的综合问卷。记录了网球、羽毛球、足球、手球、骑自行车、游泳、慢跑、健美操、健身俱乐部活动、举重和其他运动的休闲体育活动持续时间（每周分钟）。主要终点是全因死亡率，中位随访时间为25.6年。利用多变量考克斯比例风险回归分析研究了闲暇时间体育活动持续时间与全因死亡率之间的关系。结果如下：与每周休闲体育活动时间为2.6至4.5小时的参考组相比，我们发现，（风险比[HR]，1.51; 95% CI，1.29 - 1.76），对于0.1 - 2.5小时（HR，1.24; 95%CI，1.05 - 1.46），每周休闲时间体育活动超过10小时（HR，1.18; 95%CI，1.00 - 1.39）。这些关系通常与年龄、性别、教育、吸烟、饮酒和体重指数亚组（排除前5年随访）中潜在混杂因素的额外调整以及心血管疾病死亡率一致。结论：我们观察到每周休闲体育活动持续时间与心血管和全因死亡率之间存在U形关联，每周参与2.6至4.5小时的风险最低，在亚组中一致。应促进参与体育活动，但应考虑将每周参与体育活动时间过长的潜在风险纳入准则和建议。(c)2021年马约医学教育和研究基金会中心点马约临床程序。2021;96（12）：3012-3020
Objective: To investigate the association between the duration of weekly leisure-time sports activity and all-cause mortality. Methods: As part of the prospective Copenhagen City Heart Study, 8697 healthy adults completed a comprehensive questionnaire about leisure-time sports activities. Duration (minutes per week) of leisure-time sports activities was recorded for tennis, badminton, soccer, handball, cycling, swimming, jogging, calisthenics, health club activities, weightlifting, and other sports. The primary end point was all-cause mortality, and the median follow-up was 25.6 years. The association between duration of leisure-time sports activities and all-cause mortality was studied using multivariable Cox proportional hazards regression analysis. Results: Compared with the reference group of 2.6 to 4.5 hours of weekly leisure-time sports activities, we found an increased risk for all-cause mortality for those with 0 hours (hazard ratio [HR], 1.51; 95% CI, 1.29 to 1.76), for those with 0.1 to 2.5 hours (HR, 1.24; 95% CI, 1.05 to 1.46), and for those with more than 10 hours (HR, 1.18; 95% CI, 1.00 to 1.39) of weekly leisure-time sports activities. These relationships were generally consistent with additional adjustments for potential confounders among subgroups of age, sex, education, smoking, alcohol intake, and body mass index, when the first 5 years of follow-up were excluded, and for cardiovascular disease mortality. Conclusion: We observed a U-shaped association between weekly duration of leisure sports activities and cardiovascular and all-cause mortality, with lowest risk for those participating in 2.6 to 4.5 weekly hours, being consistent across subgroups. Participation in sport activities should be promoted, but the potential risk of very high weekly hours of sport participation should be considered for inclusion in guidelines and recommendations. (c) 2021 Mayo Foundation for Medical Education and Research center dot Mayo Clin Proc. 2021;96(12):3012-3020