Tumor regression is associated with a specific immune response to the E2 protein of cottontail rabbit papillomavirus.
Tumor regression is associated with a specific immune response to the E2 protein of cottontail rabbit papillomavirus.
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肿瘤消退与对棉尾兔乳头瘤病毒 E2 蛋白的特异性免疫反应有关。
DOI：
10.1006/viro.1995.1152
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
Wettstein,FO
中科院分区：
文献类型：
--
作者：
Selvakumar,R;Ahmed,R;Wettstein,FO
棉尾兔乳头瘤病毒是研究宿主-病毒相互作用的主要乳头瘤病毒动物模型。与人类乳头状瘤病毒一样，乳头状瘤可能自发消退、持续或进展为癌。在这里，我们表明大多数（88%）回归兔具有非结构蛋白E2抗体，而在持续乳头状瘤动物中为29%。退行性和持续性乳头状瘤兔对其他非结构病毒蛋白的抗体反应相同。用体外增殖法测定细胞免疫应答。对E6和E7的反应在有乳头瘤的家兔和回归家兔中少见且相似，没有家兔对E1有反应。相比之下，E2的反应在回归家兔中更为频繁。这些数据表明e2特异性免疫反应可能在肿瘤消退中起作用。
Cottontail rabbit papillomavirus is the major papillomavirus animal model with which to study host-virus interactions. As with human papillomaviruses, papillomas may spontaneously regress, persist, or progress to carcinoma. Here we show that the majority (88%) of regressor rabbits had antibody to the nonstructural protein E2 compared to 29% in animals with persisting papilloma. The antibody response to other nonstructural viral proteins was the same for rabbits with regressing and persisting papilloma. The cellular immune response was measured by an in vitro proliferation assay. The responses to E6 and E7 were infrequent and similar in papilloma-bearing and in regressor rabbits and no rabbits responded to E1. In contrast, the response to E2 was more frequent in regressor rabbits. These data suggest that E2-specific immune responses may play a role in tumor regression.